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dc.contributor.author Alvarez, Gisela Solange
dc.contributor.author Alvarez Echazú, María Inés
dc.contributor.author Olivetti, Christian Ezequiel
dc.contributor.author Desimone, Martín Federico
dc.date.available 2017-06-19T20:17:50Z
dc.date.issued 2015-02
dc.identifier.citation Alvarez, Gisela Solange; Alvarez Echazú, María Inés; Olivetti, Christian Ezequiel; Desimone, Martín Federico; Synthesis and characterization of ibandronate-loaded silica nanoparticles and collagen nanocomposites; Bentham Science Publishers; Current Pharmaceutical Biotechnology; 16; 7; 2-2015; 661-667
dc.identifier.issn 1389-2010
dc.identifier.uri http://hdl.handle.net/11336/18471
dc.description.abstract Non-porous bare silica nanoparticles, amine modified silica nanoparticles and mesoporous particles, were evaluated as carriers for sodium ibandronate. The synthesized nanoparticles were characterized by SEM, TEM, DLS and porosity. Then, their capacity to incorporate a bisphosphonate drug (sodium ibandronate) and the in vitro release behavior was analyzed by capillary electrophoresis. Mesoporous and amine-modified particles showed higher levels of drug incorporation, 44.68 mg g-1 and 28.90 mg g-1, respectively. The release kinetics from the two types of particles was similar following a first order kinetics. However, when these particles were included into collagen hydrogels only mesoporous nanoparticles had a sustained release for over 10 days. The biocompatibility of mesoporous particles towards Saos-2 cells was also evaluated by the MTT assay observing an increase in cell viability for concentrations lower than 0.6 mg ml-1 of particles and a decrease for concentrations over 1.2 mg ml-1. Furthermore, when these particles were incubated with mesenchymal cells it was observed that they had the capacity to promote the differentiation of the cells with a significant increase in the alkaline phosphatase activity.
dc.format application/pdf
dc.language.iso eng
dc.publisher Bentham Science Publishers
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Nanoparticles
dc.subject Collagen
dc.subject Ibandronate
dc.subject Silica
dc.subject.classification Nano-materiales
dc.subject.classification Nanotecnología
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Synthesis and characterization of ibandronate-loaded silica nanoparticles and collagen nanocomposites
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-06-16T21:30:38Z
dc.identifier.eissn 1873-4316
dc.journal.volume 16
dc.journal.number 7
dc.journal.pagination 661-667
dc.journal.pais Emiratos Árabes Unidos
dc.journal.ciudad Sharjah
dc.description.fil Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil Fil: Alvarez Echazú, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil Fil: Olivetti, Christian Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.journal.title Current Pharmaceutical Biotechnology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/130650/article
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/138920101607150427113355


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)