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dc.contributor.author
Bieber, Kristin  
dc.contributor.author
Günter, Manina  
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Pasquevich, Karina Alejandra  
dc.contributor.author
Autenrieth, Stella E.  
dc.date.available
2023-01-13T16:58:34Z  
dc.date.issued
2021-08  
dc.identifier.citation
Bieber, Kristin; Günter, Manina; Pasquevich, Karina Alejandra; Autenrieth, Stella E.; Systemic bacterial infections affect dendritic cell development and function; Elsevier Gmbh; International Journal of Medical Microbiology (print); 311; 6; 8-2021; 1-10  
dc.identifier.issn
1438-4221  
dc.identifier.uri
http://hdl.handle.net/11336/184702  
dc.description.abstract
Dendritic cells (DCs) are critical in host defense against infection. DC depletion is an early event in the course of sepsis that may impair the host defense mechanisms. Here, we addressed whether DC depletion and dysfunction are pathogen-independent, mediated via pattern recognition receptors, and are due to impaired DC development upon systemic infection with the Gram-negative bacterium Escherichia coli and the Gram-positive pathogen Staphylococcus aureus. Infection with E. coli and S. aureus led to reduced numbers of splenic DC subsets and of DC progenitors in the bone marrow (BM) with this effect persisting significantly longer in mice infected with S. aureus than with E. coli. The reduction of DC subsets and their progenitors was mainly TLR-independent as was the infection-induced monopoiesis. Moreover, de novo DC development was impaired in mice infected with S. aureus, and BM cells from E. coli or S. aureus infected mice favored macrophage differentiation in vitro. As a consequence of reduced DC numbers and their reduced expression of MHC II less CD4+ and CD8+ T cells, especially Th1 and IFN-γ producing CD8+ T cells, could be detected in S. aureus compared to E. coli infected mice. These differences are reflected in the rapid killing of E. coli as opposed to an increase in bacterial load in S. aureus. In summary, our study supports the idea that systemic bacterial infections generally affect the number and development of DCs and thereby the T cell responses, but the magnitude is pathogen-dependent.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Gmbh  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
DENDRITIC CELLS  
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DEVELOPMENT  
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ESCHERICHIA COLI  
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INFECTION  
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INNATE IMMUNE DEFENSE  
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MONOCYTES  
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STAPHYLOCOCCUS AUREUS  
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TLR  
dc.subject.classification
Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Systemic bacterial infections affect dendritic cell development and function  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-09-20T11:06:50Z  
dc.journal.volume
311  
dc.journal.number
6  
dc.journal.pagination
1-10  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlín  
dc.description.fil
Fil: Bieber, Kristin. University Of Tübingen; Alemania  
dc.description.fil
Fil: Günter, Manina. University Of Tübingen; Alemania. German Cancer Research Center; Alemania  
dc.description.fil
Fil: Pasquevich, Karina Alejandra. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina  
dc.description.fil
Fil: Autenrieth, Stella E.. University Of Tübingen; Alemania. German Cancer Research Center; Alemania  
dc.journal.title
International Journal of Medical Microbiology (print)  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1438422121000461  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ijmm.2021.151517