Artículo

The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis

Blanco, Federico CarlosIcon ; Garcia, Elizabeth AndreaIcon ; Aagaard, Claus; Bigi, FabianaIcon
Fecha de publicación: 05/2021
Editorial: Elsevier
Revista: Research in Veterinary Science
ISSN: 0034-5288
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

H65, a fusion protein of three pairs of ESX-secreted antigens of Mycobacterium tuberculosis and Mycobacterium bovis, formulated with the liposomal adjuvant CAF01 has been shown to confer protection against M. tuberculosis infection in mice. In this study, we evaluated the impact of combining BCG with H65 + CAF01 immunization in a M. bovis mouse model of infection. We found that a BCG-H65 + CAF01/ H65 + CAF01 prime-boost scheme induced higher protection than BCG and H65 + CAF01 alone. Altogether, H65 antigen formulated in liposomal adjuvant improved the BCG-induced immune protection, thus making this vaccine strategy a promising tool to control bovine tuberculosis.
Palabras clave: CAF01 , H65 , MYCOBACTERIUM BOVIS , VACCINE
 
Archivos asociados
Tamaño: 1.697Mb
Formato: PDF
.
Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/184656
URL: https://www.sciencedirect.com/science/article/pii/S0034528821001132
DOI: https://doi.org/10.1016/j.rvsc.2021.04.014
Colecciones
Articulos (IABIMO)
Articulos de INSTITUTO DE AGROBIOTECNOLOGIA Y BIOLOGIA MOLECULAR
Citación
Blanco, Federico Carlos; Garcia, Elizabeth Andrea; Aagaard, Claus; Bigi, Fabiana; The subunit vaccine H65 + CAF01 increased the BCG- protection against Mycobacterium bovis infection in a mouse model of bovine tuberculosis; Elsevier; Research in Veterinary Science; 136; 5-2021; 595-597
Compartir
Altmétricas