Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

Systemic and local toxicity assay of an aqueous extract of Larrea divaricata Cav.: role of NDGA

Peralta, Ignacio NahuelIcon ; Martino, Renzo FabricioIcon ; Davicino, Roberto CarlosIcon ; Gorzalczany, Susana Beatriz; Alonso, Maria del RosarioIcon ; Anesini, Claudia AlejandraIcon
Fecha de publicación: 07/2015
Editorial: Society of Pharmaceutical Sciences and Research
Revista: International Journal of Pharmaceutical Sciences and Research
ISSN: 2320-5148
e-ISSN: 0975-8232
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Farmacología y Farmacia

Resumen

Larrea divaricata Cav. (Zygophyllaceae) is an autochthonous plant of South America, widely distributed in Argentina. It is used in folk medicine as an anti-inflammatory drug. By other way, presents well documented antitumoral and immunomodulatory effects. Nordihydroguaiaretic acid (NDGA), an antioxidant compound, had been previously described in this plant. Nowadays a formulation for hair growth based on an extract of L divaricata is commercialized in Argentina. Taken these into account, the objective of this work was to determine the systemic and local toxicities of the aqueous extract of L divaricata, by giving it under oral and topical administration. Also, it was proposed to analyze the participation of NDGA in the systemic toxicity of the plant extract. The extract presented low acute toxicity, and the histopathological examination of the tissues did not show any signal of toxicity at the same time that did not affect biochemical parameters except eosinophils which were decreased by the treatment. Which is more; the extract did not exert dermatological or ocular irritation. It is important to note that in relation to its innocuousness and pharmacological properties other phytotherapy formulations could be prepared in a future.
Palabras clave: Larrea Divaricata , Ndga , Aqueous Extract , Toxicity Studies
Ver el registro completo
 
Archivos asociados
Thumbnail
 
Tamaño: 516.8Kb
Formato: PDF
.
Descargar
Licencia
info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/18459
URL: http://ijpsr.com/bft-article/systemic-and-local-toxicity-assay-of-an-aqueous-ext
Colecciones
Articulos(IQUIMEFA) [331]
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Peralta, Ignacio Nahuel; Martino, Renzo Fabricio; Davicino, Roberto Carlos; Gorzalczany, Susana Beatriz; Alonso, Maria del Rosario; et al.; Systemic and local toxicity assay of an aqueous extract of Larrea divaricata Cav.: role of NDGA; Society of Pharmaceutical Sciences and Research; International Journal of Pharmaceutical Sciences and Research; 6; 7; 7-2015; 1000-1010
Compartir
Estadísticas
Visualizaciones: 235
Descargas: 135

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • Twitter
  • Instagram
  • YouTube
  • Sound Cloud

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

Ministerio
https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES