Artículo
Systemic and local toxicity assay of an aqueous extract of Larrea divaricata Cav.: role of NDGA
Peralta, Ignacio Nahuel
; Martino, Renzo Fabricio
; Davicino, Roberto Carlos
; Gorzalczany, Susana Beatriz; Alonso, Maria del Rosario
; Anesini, Claudia Alejandra
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Fecha de publicación:
07/2015
Editorial:
Society of Pharmaceutical Sciences and Research
Revista:
International Journal of Pharmaceutical Sciences and Research
ISSN:
2320-5148
e-ISSN:
0975-8232
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Larrea divaricata Cav. (Zygophyllaceae) is an autochthonous plant of South America, widely distributed in Argentina. It is used in folk medicine as an anti-inflammatory drug. By other way, presents well documented antitumoral and immunomodulatory effects. Nordihydroguaiaretic acid (NDGA), an antioxidant compound, had been previously described in this plant. Nowadays a formulation for hair growth based on an extract of L divaricata is commercialized in Argentina. Taken these into account, the objective of this work was to determine the systemic and local toxicities of the aqueous extract of L divaricata, by giving it under oral and topical administration. Also, it was proposed to analyze the participation of NDGA in the systemic toxicity of the plant extract. The extract presented low acute toxicity, and the histopathological examination of the tissues did not show any signal of toxicity at the same time that did not affect biochemical parameters except eosinophils which were decreased by the treatment. Which is more; the extract did not exert dermatological or ocular irritation. It is important to note that in relation to its innocuousness and pharmacological properties other phytotherapy formulations could be prepared in a future.
Palabras clave:
Larrea Divaricata
,
Ndga
,
Aqueous Extract
,
Toxicity Studies
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Peralta, Ignacio Nahuel; Martino, Renzo Fabricio; Davicino, Roberto Carlos; Gorzalczany, Susana Beatriz; Alonso, Maria del Rosario; et al.; Systemic and local toxicity assay of an aqueous extract of Larrea divaricata Cav.: role of NDGA; Society of Pharmaceutical Sciences and Research; International Journal of Pharmaceutical Sciences and Research; 6; 7; 7-2015; 1000-1010
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