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dc.contributor.author
Bouzat, Cecilia Beatriz
dc.date.available
2023-01-11T16:58:14Z
dc.date.issued
2017
dc.identifier.citation
α7 at the single-channel level; Nicotinic acetylcholine receptors 2017; Grecia; 2017; 43-43
dc.identifier.uri
http://hdl.handle.net/11336/184378
dc.description.abstract
The α7 nicotinic receptor (nAChR) is expressed in brain and in non-neuronal cells. It is emerging as a drug target for cognitive deficits and inflammatory processes. We have focused on understanding α7 function at the single-channel level. We identified novel positive allosteric modulators (PAMs) and analyzed the activity of type I PAMs, which enhance macroscopic currents, and type II PAMs, which also decrease current decay rates. Regardless of their macroscopic behavior, all PAMs enhance open-channel lifetime and induce episodes of successive openings, indicating that both types affect α7 kinetics. We determined the temperature sensitivity and structural determinants for potentiation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Region of Crete
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
RECEPTOR CYS-LOOP
dc.subject
NICOTINIC RECEPTOR
dc.subject
PATCH CLAMP
dc.subject.classification
Biofísica
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
α7 at the single-channel level
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2022-04-21T17:25:44Z
dc.journal.pagination
43-43
dc.journal.pais
Grecia
dc.journal.ciudad
Chania
dc.description.fil
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina
dc.conicet.rol
Autor
dc.coverage
Internacional
dc.type.subtype
Congreso
dc.description.nombreEvento
Nicotinic acetylcholine receptors 2017
dc.date.evento
2017-05-07
dc.description.paisEvento
Grecia
dc.type.publicacion
Journal
dc.description.institucionOrganizadora
The nicotinic receptor triannual meeting
dc.source.revista
Nicotinic acetylcholine receptor 2017
dc.date.eventoHasta
2017-05-11
dc.type
Congreso
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