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dc.contributor.author
Permana, Andi Dian
dc.contributor.author
Paredes, Alejandro Javier
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dc.contributor.author
Zanutto, Fabiana Volpe
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Amir, Muh. Nur
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Ismail, Ismail
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Bahar, Muh. Akbar
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Sumarheni, null
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Palma, Santiago Daniel
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dc.contributor.author
Donnelly, Ryan F.
dc.date.available
2023-01-11T12:54:54Z
dc.date.issued
2021-08-05
dc.identifier.citation
Permana, Andi Dian; Paredes, Alejandro Javier; Zanutto, Fabiana Volpe; Amir, Muh. Nur; Ismail, Ismail; et al.; Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of Cystic Echinococcosis; American Chemical Society; ACS Applied Materials & Interfaces; 13; 32; 5-8-2021; 38745-38760
dc.identifier.issn
1944-8244
dc.identifier.uri
http://hdl.handle.net/11336/184280
dc.description.abstract
Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both humans and animals' lives. Current treatment of CE by oral administration of albendazole (ABZ) is hampered by several limitations. The poor aqueous solubility and the rapid metabolism of ABZ in the liver are the main issues, leading to lack of efficacy of the treatment. In the present study, we developed a nanocrystalline (NC) formulation of ABZ to be delivered intradermally using dissolving microneedles (DMNs). The NC formulation was developed using milling in an ultrasmall-scale device. Following several screenings, Pluronic F127 was selected as a suitable stabilizer, producing NCs with around 400 nm in size with narrow particle distribution. The crystallinity of ABZ was maintained as observed by DSC and XRD analysis. The NC approach was able to improve the dissolution percentage of ABZ by approximately three-fold. Furthermore, the incorporation of NCs into DMNs using the combination of poly(vinylpyrrolidone) and poly(vinyl alcohol) formed sharp needles with sufficient mechanical strength and insertion properties. Dermatokinetic studies revealed that >25% of ABZ was localized in the dermis of excised neonatal porcine skin up to 48 h after DMN administration. In in vivo pharmacokinetic studies, the AUC and relative bioavailability values of ABZ delivered by NC-loaded DMNs were found to be significantly higher than those obtained after oral administration of coarse suspension of ABZ or ABZ-NCs, as well as DMNs delivering coarse ABZ as indicated by the relative bioavailability values of >100%. Therefore, the combination approach developed in this study could maintain the systemic circulation of ABZ, which could be possibly caused by avoiding the first-pass metabolism in the liver. This could be beneficial to improve the efficacy of ABZ in CE treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALBENDAZOLE
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CYSTIC ECHINOCOCCOSIS
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MICRONEEDLES
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NANOCRYSTALS
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PHARMACOKINETICS
dc.subject.classification
Otras Nanotecnología
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dc.subject.classification
Nanotecnología
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Albendazole nanocrystal-based dissolving microneedles with improved pharmacokinetic performance for enhanced treatment of Cystic Echinococcosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-04-26T17:33:36Z
dc.identifier.eissn
1944-8252
dc.journal.volume
13
dc.journal.number
32
dc.journal.pagination
38745-38760
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Permana, Andi Dian. Hasanuddin University; Indonesia
dc.description.fil
Fil: Paredes, Alejandro Javier. The Queens University of Belfast; Irlanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Zanutto, Fabiana Volpe. Universidade Estadual de Campinas; Brasil. The Queens University of Belfast; Irlanda
dc.description.fil
Fil: Amir, Muh. Nur. Hasanuddin University; Indonesia
dc.description.fil
Fil: Ismail, Ismail. Hasanuddin University; Indonesia
dc.description.fil
Fil: Bahar, Muh. Akbar. Hasanuddin University; Indonesia
dc.description.fil
Fil: Sumarheni, null. Hasanuddin University; Indonesia
dc.description.fil
Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Donnelly, Ryan F.. The Queens University of Belfast; Irlanda
dc.journal.title
ACS Applied Materials & Interfaces
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acsami.1c11179
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acsami.1c11179
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