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dc.contributor.author
Stathopoulos, Christina
dc.contributor.author
Lumbroso Le Rouic, Livia
dc.contributor.author
Moll, Annette C.
dc.contributor.author
Parulekar, Manoj
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Maeder, Philippe
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Doz, François
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Jenkinson, Helen
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Popovic, Maja Beck
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Chantada, Guillermo Luis
dc.contributor.author
Munier, Francis L.
dc.date.available
2023-01-10T18:41:06Z
dc.date.issued
2021-07
dc.identifier.citation
Stathopoulos, Christina; Lumbroso Le Rouic, Livia; Moll, Annette C.; Parulekar, Manoj; Maeder, Philippe; et al.; Current indications of secondary enucleation in retinoblastoma management: A position paper on behalf of the european retinoblastoma group (EURbG); Multidisciplinary Digital Publishing Institute; Cancers; 13; 14; 7-2021; 1-18
dc.identifier.uri
http://hdl.handle.net/11336/184217
dc.description.abstract
Secondary enucleation (SE) puts an irreversible end to eye-preserving therapies, whenever their prolongation is expected to violate the presumed state of metastatic grace. At present, it must be acknowledged that clear criteria for SE are missing, leading to empiric and subjective indications commonly related to disease progression or relapse, disease persistence masking the optic nerve head or treatment-related complications obscuring the fundus view. This absence of evidence-based consensus regarding SE is explained by the continuously moving frontiers of the conservative management as a result of diagnostic and therapeutic advances, as well as by the lack of studies sufficiently powered to accurately stratify the risk of metastasis in conservatively treated patients. In this position paper of the European Retinoblastoma Group (EURbG), we give an overview of the progressive shift in the indications for SE over the past decades and propose guidelines to assist decision-making with respect to when SE becomes imperative or recommended, with corresponding absolute and relative SE indications. Further studies and validation of biologic markers correlated with the risk of metastasis are expected to set more precisely the frontiers of conservative management and thus consensual criteria for SE in the future.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
EXTERNAL BEAM IRRADIATION
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INTRA-ARTERIAL CHEMOTHERAPY
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INTRAVENOUS CHEMOTHERAPY
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METASTASIS
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RETINOBLASTOMA
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SECONDARY ENUCLEATION
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SURVIVAL
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Current indications of secondary enucleation in retinoblastoma management: A position paper on behalf of the european retinoblastoma group (EURbG)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T14:10:40Z
dc.identifier.eissn
2072-6694
dc.journal.volume
13
dc.journal.number
14
dc.journal.pagination
1-18
dc.journal.pais
Suiza
dc.description.fil
Fil: Stathopoulos, Christina. Universite de Lausanne; Suiza
dc.description.fil
Fil: Lumbroso Le Rouic, Livia. Institut Curie; Francia
dc.description.fil
Fil: Moll, Annette C.. Vrije Universiteit Amsterdam; Países Bajos
dc.description.fil
Fil: Parulekar, Manoj. Birmingham Children's Hospital; Reino Unido
dc.description.fil
Fil: Maeder, Philippe. Centre Hospitalier Universitaire Vaudois; Suiza
dc.description.fil
Fil: Doz, François. Université de Paris; Francia
dc.description.fil
Fil: Jenkinson, Helen. Birmingham Women’s and Children’s NHS Foundation Trust; Reino Unido
dc.description.fil
Fil: Popovic, Maja Beck. Centre Hospitalier Universitaire Vaudois; Suiza
dc.description.fil
Fil: Chantada, Guillermo Luis. Hospital Sant Joan de Deu Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Munier, Francis L.. Universite de Lausanne; Suiza
dc.journal.title
Cancers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/cancers13143392
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6694/13/14/3392
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