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dc.contributor.author
Suasnábar, Santiago Martín  
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Olivera, Lorena Veronica  
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Arias, Evelyn  
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Bizai, María Laura  
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Bottasso, Oscar Adelmo  
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Arias, Enrique  
dc.contributor.author
Fabbro, Diana Lucrecia  
dc.date.available
2023-01-10T10:49:17Z  
dc.date.issued
2021-10  
dc.identifier.citation
Suasnábar, Santiago Martín; Olivera, Lorena Veronica; Arias, Evelyn; Bizai, María Laura; Bottasso, Oscar Adelmo; et al.; Trypanocidal therapy among children infected by Trypanosoma cruzi: Serological and electrocardiographic changes over a mean twenty-five-years follow-up period; Elsevier Science; Acta Tropica; 222; 10-2021; 1-7  
dc.identifier.issn
0001-706X  
dc.identifier.uri
http://hdl.handle.net/11336/184035  
dc.description.abstract
This study compared the serological and electrocardiographic evolution among patients with chronic T. cruzi infection treated during childhood or left untreated. A retrospective cohort study was conducted during a mean follow-up period of 25 years in 82 patients: half of them underwent treatment (nifurtimox 8, benznidazole 33) before being 15 years old, whereas the other half remained untreated. During the follow-up, negative seroconversion occurred in 92.7% of the treated children, while all the untreated ones remained positive for conventional serology. At baseline, 2 patients from each group had electrocardiographic abnormalities. During the study period, 4/41 (9.75%) and 9/41 (21.95%) of treated and untreated patients displayed an altered electrocardiogram, respectively. In multivariate analyses, the probability of developing electrocardiographic abnormalities was significantly reduced among treated patients (OR = 0.18, 95% CI = 0.04-0.79; p = 0.023). Electrocardiographic abnormalities attributable to Chagas cardiomyopathy were seen in 3 patients from the untreated group (complete right bundle branch block + left anterior fascicular block, frequent ventricular extrasystole, and left anterior fascicular block). The remarkable seronegativization seen in Benznidazole and Nifurtimox recipients underlines the parasiticidal effect of both compounds. Such demonstration along with the fact that CCC-related alterations were only present in the untreated group, reinforces the view of trypanocidal treatment in chronically T. cruzi-infected children as decreasing the risk for cardiomyopathy development.  
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application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CARDIOMYOPATHY  
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CHAGAS DISEASE  
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CHRONIC INFECTION  
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FOLLOW-UP 1  
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TRYPANOCIDAL THERAPY  
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TRYPANOSOMA CRUZI  
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Otros tipos de Medicina Clínica  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Trypanocidal therapy among children infected by Trypanosoma cruzi: Serological and electrocardiographic changes over a mean twenty-five-years follow-up period  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-10-06T10:42:15Z  
dc.journal.volume
222  
dc.journal.pagination
1-7  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Suasnábar, Santiago Martín. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Investigaciones sobre Endemias Nacionales; Argentina  
dc.description.fil
Fil: Olivera, Lorena Veronica. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Investigaciones sobre Endemias Nacionales; Argentina  
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Fil: Arias, Evelyn. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Investigaciones sobre Endemias Nacionales; Argentina  
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Fil: Bizai, María Laura. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Investigaciones sobre Endemias Nacionales; Argentina  
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Fil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina  
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Fil: Arias, Enrique. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Investigaciones sobre Endemias Nacionales; Argentina  
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Fil: Fabbro, Diana Lucrecia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Centro de Investigaciones sobre Endemias Nacionales; Argentina  
dc.journal.title
Acta Tropica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.actatropica.2021.106050