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Artículo

Anti-inflammatory and antinociceptive activity of urera aurantiaca

Riedel, Rodrigo NicolasIcon ; Marrassini, CarlaIcon ; Anesini, Claudia AlejandraIcon ; Gorzalczany, Susana Beatriz
Fecha de publicación: 09/2014
Editorial: Wiley
Revista: Phytotherapy Research
ISSN: 0951-418X
e-ISSN: 1099-1573
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias de la Salud

Resumen

Urera aurantiaca Wedd. (Urticaceae) is a medicinal plant commonly used in traditional medicine to relieve pain in inflammatory processes. In the present study, the in vivo anti-inflammatory and antinociceptive effects of U. aurantiaca methanolic extract and its possible mechanisms of action were investigated. The extract showed anti-inflammatory activity in the ear edema in mice test (34.3% inhibition), myeloperoxidase (MPO) activity was markedly reduced in animals administered with the extract: within 49.6% and 68.5%. In the histological analysis, intense dermal edema and intense cellular infiltration of inflammatory cells were markedly reduced in the ear tissue of the animals treated with the extract. In the carrageenan-induced hind paw edema in rats assay the extract provoked a significant inhibition of the inflammation (45.5%, 5 h after the treatment) and the MPO activity was markedly reduced (maximum inhibition 71.7%), The extract also exhibited significant and dose-dependent inhibitory effect on the increased vascular permeability induced by acetic acid. The extract presented antioxidant activity in both 2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis 3-ethylbenzothiazoline 6-sulfonic acid tests and its total phenol content was 35.4 ± 0.06 mg GAE/g of extract. Also, the extract produced significant inhibition on nociception induced by acetic acid (ED50: 8.7 mg/kg, i.p.) administered intraperitoneally and orally. Naloxone significantly prevented this activity.
Palabras clave: Urera Aurantiaca , Anti-Inflammatory Activity , Antinociceptive Activity , Antioxidant Activity , In Vivo
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/18382
URL: http://onlinelibrary.wiley.com/doi/10.1002/ptr.5226/abstract
DOI: http://dx.doi.org/10.1002/ptr.5226
Colecciones
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Riedel, Rodrigo Nicolas; Marrassini, Carla; Anesini, Claudia Alejandra; Gorzalczany, Susana Beatriz; Anti-inflammatory and antinociceptive activity of urera aurantiaca; Wiley; Phytotherapy Research; 29; 1; 9-2014; 59-66
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