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dc.contributor.author
Roca, Valeria Ines
dc.contributor.author
Puntel, Mariana
dc.date.available
2017-06-16T19:02:26Z
dc.date.issued
2013-11
dc.identifier.citation
Roca, Valeria Ines; Puntel, Mariana; LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease; IOS Press; Advances in Neuroimmune Biology; 4; 3; 11-2013; 205-215
dc.identifier.issn
1878-9498
dc.identifier.uri
http://hdl.handle.net/11336/18331
dc.description.abstract
The pathogenetic mechanisms leading to typical Parkinson's Disease (PD), the second most common human neurodegenerative disorder remains unknown. Genetic variants of Leucine-Rich Repeat Kinase 2 (LRRK-2) are associated with a significantly enhanced risk for PD. The discovery that late-onset PD could be caused by the inheritance of a mutation in the LRRK-2 gene leading to familial as well as sporadic forms of PD has provided researchers an opportunity to explore the pathophysiological events underlying this complex disease. Despite extensive research our understanding of LRRK-2 biological function and regulation remains rudimentary. In this review, we give an insight into the role of LRRK-2 in modulating inflammation in the central nervous system and we hypothesize that LRRK-2 dysfunction may favor the neurodegenerative process observed in PD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IOS Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Neuroinflammation
dc.subject
Parkinsons Disease
dc.subject
Lrrk 2
dc.subject
Cytoquines
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
Otras Ciencias Médicas
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
LRRK-2 as a Key Molecule Bridging Inflammation to Parkinson's Disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-05T13:13:01Z
dc.journal.volume
4
dc.journal.number
3
dc.journal.pagination
205-215
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Puntel, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.journal.title
Advances in Neuroimmune Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://content.iospress.com/articles/advances-in-neuroimmune-biology/nib130067
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3233/NIB-130067


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