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dc.contributor.author
Sieira, Rodrigo
dc.date.available
2017-06-16T19:01:04Z
dc.date.issued
2013-09
dc.identifier.citation
Sieira, Rodrigo; Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter; Future Medicine; Future Microbiology; 8; 9; 9-2013; 1193-1208
dc.identifier.issn
1746-0913
dc.identifier.uri
http://hdl.handle.net/11336/18330
dc.description.abstract
Many intracellular bacterial pathogens use type IV secretion systems to deliver effector molecules and subvert the eukaryotic host cell defenses. The genus Brucella comprises facultative intracellular bacteria that cause brucellosis, a disease affecting a wide range of mammals including humans. The virB operon codes for a type IV secretion system that plays a central role in intracellular survival and replication of Brucella within the host. Expression of the virB genes is under the control of various transcription factors that allow this system to respond to different types of environmental signals, and display binding site structures and arrangements that define the intrinsic complexity of the virB promoter. This review focuses on summarizing the current state of research concerning regulation of the Brucella virB operon, with special emphasis on describing the nature and function of the implicated regulatory elements and examining the involved protein-DNA interactions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Future Medicine
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Brucella
dc.subject
Type Iv Secretion System
dc.subject
Virb
dc.subject
Regulation
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-05T13:13:02Z
dc.identifier.eissn
1746-0921
dc.journal.volume
8
dc.journal.number
9
dc.journal.pagination
1193-1208
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.journal.title
Future Microbiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/pdf/10.2217/fmb.13.83
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2217/fmb.13.83


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