Development of an inverse-PCR approach for characterization of the major BCR-ABL1 breakpoint sequences on genomic DNA: Proof of concept

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Philadelphia chromosome, which contains the BCR-ABL1 fusion gene. The international conventional standardized method for routine monitoring of CML patients under tyrosine kinase inhibitor therapy is based on real-time quantitative reverse transcription-PCR (qRT-PCR) of BCR-ABL1...

Palabras clave: CHRONIC MYELOID LEUKEMIA , DNA BREAKPOINT JUNCTION , GENOMIC BCR-ABL1 , INVERSE-PCR

Ver el registro completo

Archivos asociados

Tamaño: 742.9Kb

Formato: PDF

Solicitar

Licencia

Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/183253

DOI: http://dx.doi.org/10.1515/cclm-2020-1482

Colecciones

Articulos(IMEX)
Articulos de INST.DE MEDICINA EXPERIMENTAL

Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES

Citación

Gutierrez, Leandro German; Abelleyro, Miguel Martin; Ruiz, María Sol; Anchordoqui, María Sol; Freitas, Josefina; et al.; Development of an inverse-PCR approach for characterization of the major BCR-ABL1 breakpoint sequences on genomic DNA: Proof of concept; De Gruyter; Clinical Chemistry and Laboratory Medicine; 59; 12; 6-2021; 449-453

Altmétricas