Artículo

A solid- and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines

Boggian, Dora Bernarda; Cornier, Patricia GriseldaIcon ; Mata, Ernesto GabinoIcon ; Blank, Viviana ClaudiaIcon ; Cárdenas, Mariano GonzaloIcon ; Roguin, Leonor PatriciaIcon
Fecha de publicación: 03/2015
Editorial: Royal Society of Chemistry
Revista: Medicinal Chemistry Communications
ISSN: 2040-2503
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

We described the design, synthesis and antiproliferative properties of a series of twenty 2β-methyl substituted penicillin derivatives. This analysis includes evaluation against HeLa and MCF-7 human tumor cell lines and LM3 and B16-F0 murine tumor cell lines. The epithelial cell line derived from the normal mammary gland of mice (NMuMG) and the mouse embryo fibroblastcell line (3T3) were used as controls (non-cancer cells).
Palabras clave: Penicillin Derivatives , Growth Inhibition , Tumor Cells , Structure-Activity Relationship
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/18325
DOI: http://dx.doi.org/10.1039/c4md00430b
Colecciones
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos(IQUIR)
Articulos de INST.DE QUIMICA ROSARIO
Citación
Boggian, Dora Bernarda; Cornier, Patricia Griselda; Mata, Ernesto Gabino; Blank, Viviana Claudia; Cárdenas, Mariano Gonzalo; et al.; A solid- and solution-phase-based library of 2β-methyl substituted penicillin derivatives and their effects on growth inhibition of tumor cell lines; Royal Society of Chemistry; Medicinal Chemistry Communications; 6; 4; 3-2015; 619-625
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