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dc.contributor.author
Pascuan, Cecilia Gabriela
dc.contributor.author
Urán, Soledad Lucía
dc.contributor.author
Gonzalez Murano, Maria Rosa
dc.contributor.author
Wald, Miriam Ruth
dc.contributor.author
Guelman, Laura Ruth
dc.contributor.author
Genaro, Ana Maria
dc.date.available
2015-08-26T18:18:25Z
dc.date.issued
2013-07
dc.identifier.citation
Pascuan, Cecilia Gabriela; Urán, Soledad Lucía; Gonzalez Murano, Maria Rosa; Wald, Miriam Ruth; Guelman, Laura Ruth; et al.; Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice; Informa Healthcare; Journal of Immunotoxicology; 11; 1; 7-2013; 78-83
dc.identifier.issn
1547-691X
dc.identifier.uri
http://hdl.handle.net/11336/1831
dc.description.abstract
Exposure to loud noise levels represents a problem in all regions of the world. Noise exposure is known to affect auditory structures in living organisms. However, it should not be ignored that many of the effects of noise are extra-auditory. In particular, it has been proposed that noise could affect immune system similarly to other stressors. Nevertheless, only few studies so far have investigated the effects of noise on the immune function. The aim of the present work was to investigate the effect of chronic (2 wk) noise (95-97 dB) exposure on immune responses in BALB/c and C57 mice. To ascertain if the effect of noise is similar to other psychological stressors, the effect of chronic restraint –applied for the same time- on immune response was also analyzed. It was found that chronic noise impaired immune-related endpoints in vivo and ex vivo depending on the strain used. Noise, but not restraint, affected C57Bl/6 mouse T-cell-dependent antibody production and ex vivo stimulated T-cell proliferation but had no effect on these parameters in BALB/c mice or their cells. In fact, none of the stressors altered T-cell responses associated with the BALB/c mice. Further, noise exposure induced a decrease in corticosterone and catecholamines levels in BALB/c mice. In contrast, no differences were seen in these parameters for those BALB/c mice under restraint or for that matter C57Bl/6 mice exposed to restraint or noise. The results of these studies indicate that noise could seriously affect immune responses in susceptible individuals. In addition, it may also be concluded that noise possibility should not be considered a classic stressor.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Informa Healthcare
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Stress
dc.subject
Corticosterone
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Catecholamines
dc.subject
Restraint
dc.subject
Antibody Production
dc.subject
Noise
dc.subject
Mice
dc.subject
T-Cell Proliferation
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Immune Alterations Induced by Chronic Noise Exposure: Comparison with Restraint Stress in BALB/c and C57Bl/6 Mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1547-6901
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
78-83
dc.journal.pais
Reino Unido
dc.journal.ciudad
London
dc.description.fil
Fil: Pascuan, Cecilia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
dc.description.fil
Fil: Urán, Soledad Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
dc.description.fil
Fil: Gonzalez Murano, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
dc.description.fil
Fil: Wald, Miriam Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
dc.description.fil
Fil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
dc.description.fil
Fil: Genaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina;
dc.journal.title
Journal of Immunotoxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/DOI:10.3109/1547691X.2013.800171
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://informahealthcare.com/doi/abs/10.3109/1547691X.2013.800171
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/1547691X.2013.800171#abstract
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