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Artículo

Morphological and functional effects on cardiac tissue induced by moderate zinc deficiency during prenatal and postnatal life in male and female rats

Tomat, Analia LorenaIcon ; Juriol, Lorena VanesaIcon ; Gobetto, María NataliaIcon ; Veiras, Luciana Cecilia; Mendes Garrido Abregú, FacundoIcon ; Zilberman, Judith Miriam; Fasoli, Hector; Elesgaray, RosanaIcon ; Costa, María Ángeles; Arranz, Cristina TeresaIcon
Fecha de publicación: 12/2013
Editorial: American Physiological Society
Revista: American Journal of Physiology - Heart and Circulatory Physiology
ISSN: 0363-6135
e-ISSN: 1522-1539
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

The aim of this study was to evaluate whether moderate zinc restriction in rats throughout fetal life, lactation, and/or postweaning growth results in early changes in cardiac morphology predisposing the onset of cardiac dysfunction in adult life as well as sex-related differences in the adaptation to this nutritional injury. Female Wistar rats received low or control zinc diets from the beginning of pregnancy up to offspring weaning. After being weaned, offspring were fed either a low or control zinc diet until 81 days. Systolic blood pressure was measured. Echocardiographic and electrocardiographic examinations, morphological experiments, and apoptosis by TUNEL assay were performed in the left ventricle. In the early stages, zinc-deficient male and female offspring showed an increase in cardiomyocyte diameter, probably associated with an increase in cardiac apoptotic cells, but smaller myocyte diameters in adulthood. In adult males, this nutritional injury induced decreased contractility and dilatation of the left ventricle, not allowing the heart to compensate the higher levels of blood pressure, and hypertrophic remodeling of coronary arteries associated with increased blood pressure. Adequate zinc intake during postweaning life did not overcome blood pressure levels but reversed some of the detrimental effects of earlier zinc deficiency in cardiac morphology and function. Females were less sensitive to this deficiency, exhibiting normal levels of blood pressure and no structural or functional heart alterations in adult life. The present study demonstrates that the effects of zinc deficiency on blood pressure, cardiac morphology, and function differ between sexes, with males more predisposed to develop cardiovascular diseases in adulthood.
Palabras clave: HEART MORPHOLOGY AND FUNCTION , MODERATE ZINC DEFICIENCY , PRENATAL AND POSTNATAL GROWTH , SEX DIFFERENCES
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/182778
DOI: http://dx.doi.org/10.1152/ajpheart.00578.2013
URL: https://journals.physiology.org/doi/full/10.1152/ajpheart.00578.2013
Colecciones
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Tomat, Analia Lorena; Juriol, Lorena Vanesa; Gobetto, María Natalia; Veiras, Luciana Cecilia; Mendes Garrido Abregú, Facundo; et al.; Morphological and functional effects on cardiac tissue induced by moderate zinc deficiency during prenatal and postnatal life in male and female rats; American Physiological Society; American Journal of Physiology - Heart and Circulatory Physiology; 305; 11; 12-2013; 1574-1583
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