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dc.contributor.author
Engelke, D. S.
dc.contributor.author
Zhang, X. O.
dc.contributor.author
O’Malley, J. J.
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Fernandez Leon, Jose Alberto
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Li, S.
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Kirouac, G. J.
dc.contributor.author
Beierlein, M.
dc.contributor.author
Do Monte, F. H.
dc.date.available
2022-12-28T14:54:36Z
dc.date.issued
2021-05
dc.identifier.citation
Engelke, D. S.; Zhang, X. O.; O’Malley, J. J.; Fernandez Leon, Jose Alberto; Li, S.; et al.; A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats; Nature; Nature Communications; 12; 1; 5-2021; 1-19
dc.identifier.issn
2041-1723
dc.identifier.uri
http://hdl.handle.net/11336/182720
dc.description.abstract
Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat conflict test in rats, we identified a subpopulation of neurons in the anterior portion of the paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) and are preferentially recruited during conflict. Inactivation of aPVTCRF neurons during conflict biases animal’s response toward food, whereas activation of these cells recapitulates the food-seeking suppression observed during conflict. aPVTCRF neurons project densely to the nucleus accumbens (NAc), and activity in this pathway reduces food seeking and increases avoidance. In addition, we identified the ventromedial hypothalamus (VMH) as a critical input to aPVTCRF neurons, and demonstrated that VMH-aPVT neurons mediate defensive behaviors exclusively during conflict. Together, our findings describe a hypothalamic-thalamostriatal circuit that suppresses reward-seeking behavior under the competing demands of avoiding threats.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
paraventricular thalamic nucleus
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reward
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avoidance
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food seeking
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Ciencias de la Información y Bioinformática
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Ciencias de la Computación e Información
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CIENCIAS NATURALES Y EXACTAS
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-12T07:43:47Z
dc.journal.volume
12
dc.journal.number
1
dc.journal.pagination
1-19
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Engelke, D. S.. The University of Texas Health Science Center; Estados Unidos
dc.description.fil
Fil: Zhang, X. O.. The University of Texas Health Science Center; Estados Unidos
dc.description.fil
Fil: O’Malley, J. J.. The University of Texas Health Science Center; Estados Unidos
dc.description.fil
Fil: Fernandez Leon, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aire. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. Sede Olavarría del Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; Argentina
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Fil: Li, S.. University of Manitoba; Canadá
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Fil: Kirouac, G. J.. University of Manitoba; Canadá
dc.description.fil
Fil: Beierlein, M.. The University of Texas Health Science Center; Estados Unidos
dc.description.fil
Fil: Do Monte, F. H.. The University of Texas Health Science Center; Estados Unidos
dc.journal.title
Nature Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41467-021-22730-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41467-021-22730-y
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