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dc.contributor.author
Linck, Viviane M.
dc.contributor.author
Ganzella, Marcelo
dc.contributor.author
Herrmann, Ana P.
dc.contributor.author
Okunji, Christopher O.
dc.contributor.author
Souza, Diogo O.
dc.contributor.author
Antonelli, Marta Cristina
dc.contributor.author
Elisabetsky, Elaine
dc.date.available
2022-12-28T11:26:02Z
dc.date.issued
2015-01
dc.identifier.citation
Linck, Viviane M.; Ganzella, Marcelo; Herrmann, Ana P.; Okunji, Christopher O.; Souza, Diogo O.; et al.; Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida); Elsevier Gmbh; Phytomedicine; 22; 1; 1-2015; 52-55
dc.identifier.issn
0944-7113
dc.identifier.uri
http://hdl.handle.net/11336/182647
dc.description.abstract
Alstonine is the major component of plant based remedies that traditional psychiatrists use in Nigeria. Alstonine is an indole alkaloid that has an antipsychotic experimental profile comparable with that of clozapine and is compatible with the alleged effects in mental patients. Representing a desirable innovation in the pharmacodynamics of antipsychotic medications, the evidence indicates that alstonine does not bind to D2 dopamine receptors (D2R) and differentially regulates dopamine in the cortical and limbic areas. The purpose of this study was to further investigate the effects of alstonine on D2R binding in specific brain regions using quantitative autoradiography (QAR) and its effects on dopamine (DA) uptake in mouse striatal synaptosomes. The effects of alstonine on D2R binding were determined in the nucleus accumbens and caudate-putamen using QAR in mice treated with alstonine doses that have antipsychotic effects. The effects of alstonine [3H]DA uptake were assessed in synaptosomes prepared from striatal tissue obtained from mice treated acutely or for 7 days with alstonine. Alstonine did not change the D2R binding densities in the studied regions. DA uptake was increased after acute (but not after 7 days) treatment with alstonine. Consistent with the alstonine behavioral profile, these results indicate that alstonine indirectly modulates DA receptors, specifically by modulating DA uptake. This unique mechanism for DA transmission modulation contributes to the antipsychotic-like effects of alstonine and is compatible with its behavioral profile in mice and alleged effects in patients. These results may represent an innovation in the antipsychotic development field.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Gmbh
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
ALSTONINE
dc.subject
ANTIPSYCHOTICS
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D2 DOPAMINE RECEPTOR
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DOPAMINE UPTAKE
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INDOLE ALKALOID
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PICRALIMA NITIDA
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SCHIZOPHRENIA
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-12-27T12:21:45Z
dc.identifier.eissn
1618-095X
dc.journal.volume
22
dc.journal.number
1
dc.journal.pagination
52-55
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Linck, Viviane M.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Ganzella, Marcelo. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Herrmann, Ana P.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Okunji, Christopher O.. International Centre for Ethnomedicine and Drug Development; Nigeria
dc.description.fil
Fil: Souza, Diogo O.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil
Fil: Elisabetsky, Elaine. Universidade Federal do Rio Grande do Sul; Brasil
dc.journal.title
Phytomedicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phymed.2014.10.010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0944711314003651
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