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dc.contributor.author
Mompeón, Ana
dc.contributor.author
Lázaro Franco, Macarena
dc.contributor.author
Bueno Betí, Carlos
dc.contributor.author
Pérez Cremades, Daniel
dc.contributor.author
Vidal Gómez, Xavier
dc.contributor.author
Monsalve, Elena
dc.contributor.author
Gironacci, Mariela Mercedes
dc.contributor.author
Hermenegildo, Carlos
dc.contributor.author
Novella, Susana
dc.date.available
2017-06-15T17:52:47Z
dc.date.issued
2016-02
dc.identifier.citation
Mompeón, Ana; Lázaro Franco, Macarena; Bueno Betí, Carlos; Pérez Cremades, Daniel; Vidal Gómez, Xavier; et al.; Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production.; Elsevier Ireland; Molecular And Cellular Endocrinology; 422; 2-2016; 1-8
dc.identifier.issn
0303-7207
dc.identifier.uri
http://hdl.handle.net/11336/18259
dc.description.abstract
Intracellular renin-angiotensin system (RAS) can operate independently of the circulating RAS. Estrogens provide protective effects by modulating the RAS. Our aim was to investigate the effect of estradiol (E2) on angiotensin converting enzymes (ACE) 1 and ACE2 expression and activities in human endothelial cells (HUVEC), and the role of estrogen receptors (ER). The results confirmed the presence of active intracellular RAS in HUVEC. Physiological concentrations of E2 induced a concentration-dependent increase of ACE1 and ACE2 mRNA expression and ACE1, but not ACE2, protein levels. ACE1 and ACE2 enzymatic activities were also induced with E2. These effects were mediated through ERα activation, since ER antagonists ICI 182780 and MPP completely abolished the effect of E2. Moreover, the ERα agonist PPT mirrored the E2 effects on ACE1 and ACE2 protein expression and activity. Exposure of endothelial cells to E2 significantly increased Ang-(1–7) production. In conclusion, E2 increases Ang-(1–7) production, through ERα, involving increased ACE1 and ACE2 mRNA expression and activity and ACE1 protein levels.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Estrogen
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Endothelial Cell
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Angiotensin Converting Enzymes
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Renin Angiotensin System
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Estrogen Receptor
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Bioquímica y Biología Molecular
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Estradiol, acting through ERα, induces endothelial non-classic renin-angiotensin system increasing angiotensin 1-7 production.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-15T17:36:45Z
dc.journal.volume
422
dc.journal.pagination
1-8
dc.journal.pais
Irlanda
dc.journal.ciudad
Shannon
dc.description.fil
Fil: Mompeón, Ana. Universidad de Valencia; España
dc.description.fil
Fil: Lázaro Franco, Macarena. Universidad de Valencia; España
dc.description.fil
Fil: Bueno Betí, Carlos. Universidad de Valencia; España
dc.description.fil
Fil: Pérez Cremades, Daniel. Universidad de Valencia; España
dc.description.fil
Fil: Vidal Gómez, Xavier. Universidad de Valencia; España
dc.description.fil
Fil: Monsalve, Elena. Universidad de Valencia; España
dc.description.fil
Fil: Gironacci, Mariela Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Hermenegildo, Carlos. Universidad de Valencia; España
dc.description.fil
Fil: Novella, Susana. Universidad de Valencia; España
dc.journal.title
Molecular And Cellular Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0303720715301295
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.mce.2015.11.004
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