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dc.contributor.author
Arza, Patricia Raquel
dc.contributor.author
Netti, Vanina Alejandra
dc.contributor.author
Perosi, Francisco
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Cernadas, Gustavo
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Ochoa, Federico Claudio
dc.contributor.author
Magnani, Natalia Daniela
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Evelson, Pablo Andrés
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Zotta, Elsa
dc.contributor.author
Fellet, Andrea L.
dc.contributor.author
Balaszczuk, Ana Maria
dc.date.available
2022-12-27T18:17:20Z
dc.date.issued
2015-02
dc.identifier.citation
Arza, Patricia Raquel; Netti, Vanina Alejandra; Perosi, Francisco; Cernadas, Gustavo; Ochoa, Federico Claudio; et al.; Involvement of nitric oxide and caveolins in the age-associated functional and structural changes in a heart under osmotic stress; Elsevier France-Editions Scientifiques Medicales Elsevier; Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie; 69; 2-2015; 380-387
dc.identifier.issn
0753-3322
dc.identifier.uri
http://hdl.handle.net/11336/182596
dc.description.abstract
Previous work done in our laboratory showed that water restriction during 24 and 72. h induced changes in cardiovascular NOS activity without altering NOS protein levels in young and adult animals. These findings indicate that the involvement of NO in the regulatory mechanisms during dehydration depends on the magnitude of the water restriction and on age. Our aim was to study whether a controlled water restriction of 1 month affects cardiac function, NO synthase (NOS) activity and NOS, and cav-1 and -3 protein levels in rats during aging. Male Sprague-Dawley rats aged 2 and 16 months were divided into 2 groups: (CR) control restriction (WR) water restriction. Measurements of arterial blood pressure, heart rate, oxidative stress, NOS activity and NOS/cav-1 and -3 protein levels were performed. Cardiac function was evaluated by echocardiography. The results showed that adult rats have greater ESV, EDV and SV than young rats with similar SBP. Decreased atria NOS activity was caused by a reduction in NOS protein levels. Adult animals showed increased cav-1. Water restriction decreased NOS activity in young and adult rats associated to an increased cav-1. TBARS levels increased in adult animals. Higher ventricular NOS activity in adulthood would be caused by a reduction in both cav. Water restriction reduced NOS activity and increased cav in both age groups. In conclusion, our results indicated that dehydration modifies cardiac NO system activity and its regulatory proteins cav in order to maintain physiological cardiac function. Functional alterations are induced by the aging process as well as hypovolemic state.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier France-Editions Scientifiques Medicales Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
AGING
dc.subject
CARDIAC MORPHOLOGY
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CAVEOLINS
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HEART NITRIC OXIDE
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WATER RESTRICTION
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Involvement of nitric oxide and caveolins in the age-associated functional and structural changes in a heart under osmotic stress
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-12-27T12:21:00Z
dc.journal.volume
69
dc.journal.pagination
380-387
dc.journal.pais
Francia
dc.journal.ciudad
París
dc.description.fil
Fil: Arza, Patricia Raquel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina
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Fil: Netti, Vanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Perosi, Francisco. Ministerio de Defensa. Fuerza Aerea Argentina; Argentina
dc.description.fil
Fil: Cernadas, Gustavo. Ministerio de Defensa. Fuerza Aerea Argentina; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Ochoa, Federico Claudio. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina
dc.description.fil
Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Evelson, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Zotta, Elsa. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina
dc.description.fil
Fil: Fellet, Andrea L.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.description.fil
Fil: Balaszczuk, Ana Maria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.journal.title
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.biopha.2014.12.026
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0753332214002212
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