Artículo
Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets
Bazzano, María Victoria
; Torelli, Carolina; Pustovrh, María Carolina
; Paz, Dante Agustin
; Elia, Evelin Mariel
Fecha de publicación:
11/2015
Editorial:
Elsevier
Revista:
Reproductive Biomedicine Online
ISSN:
1472-6483
e-ISSN:
1472-6491
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Obesity constitutes a health problem of increasing worldwide prevalence. Among the health detriments caused by obesity, reproduction is disrupted. However, the mechanisms involved in this disruption are not fully understood. Animals fed a cafeteria diet constitute the model for the study of obesity that most closely reflects Western diet habits. The aims of this study were to evaluate whether a cafeteria diet affects ovarian function and to contribute to the understanding of the mechanisms involved. For that purpose, 22-day-old female Wistar rats were fed ad libitum with a standard diet (control group; n = 20) or cafeteria diet (CAF group; n = 20). The cafeteria diet induced obesity and hyperglycaemia, without altering serum triglycerides, cholesterol or C-reactive protein concentrations. This diet also altered ovarian function: the rats showed prolonged dioestrous phases, decreased serum oestradiol concentrations and increased number of antral atretic follicles. Moreover, follicular cysts were detected in the CAF group, concomitantly with a decrease in the number of anti-Müllerian hormone immunoreactive pre-antral follicles and COX-2-positive antral and pre-ovulatory follicles. The authors conclude that a cafeteria diet reduces ovarian reserve, induces the presence of follicular cysts and disturbs the ovulatory process, leading to the delayed pregnancy observed in these animals.
Palabras clave:
FERTILITY
,
ANTI-MÜLLERIAN HORMONE
,
FOLLICULAR CYST
,
FOLLICULOGENESIS
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Licencia
Identificadores
Colecciones
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Bazzano, María Victoria; Torelli, Carolina; Pustovrh, María Carolina; Paz, Dante Agustin; Elia, Evelin Mariel; Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets; Elsevier; Reproductive Biomedicine Online; 31; 5; 11-2015; 655-667
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