Artículo
TNF-α enhances estrogen-induced cell proliferation of estrogen-dependent breast tumor cells through a complex containing nuclear factor-kappa B
Rubio, Maria Fernanda
; Werbajh, Santiago Enrique
; Cafferata, Eduardo Gustavo Alfredo
; Quaglino, Ana
; Colo, Georgina Pamela
; Nojek Barbieri, Ignacio Martin
; Kordon, Edith Claudia
; Nahmod, Victor Elias; Costas, Monica Alejandra
Fecha de publicación:
03/2006
Editorial:
Nature Publishing Group
Revista:
Oncogene
ISSN:
0950-9232
e-ISSN:
1476-5594
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Breast tumors are usually classified according to their response to estrogens as hormone-dependent or -independent. In this work, we investigated the role of the proinflammatory cytokine TNF-α on the estrogen-receptor- positive T47D breast ductal tumor cells. We have found that TNF-α exerts a mitogenic effect, inducing cyclin D1 expression and activation of the transcription factor NF-κB. Importantly, activation of NF-κB was required for estrogen-induced proliferation and cyclin D1 expression. TNF-α enhanced the estrogen response by increasing the levels and availability of NF-κB. Chromatin immunoprecipitation analysis suggested that the action of estrogens is mediated by a protein complex that contains the activated estrogen receptor, the nuclear receptor coactivator RAC3 and a member of the NF-κB family. Finally, our results demonstrate that activation of this transcription factor could be one of the key signals for estrogen-mediated response. © 2006 Nature Publishing Group All rights reserved.
Palabras clave:
BREAST TUMOR
,
ESTROGEN RECEPTOR
,
NF-KB
,
NUCLEAR RECEPTOR COACTIVATORS
,
TNF-A
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IDIM)
Articulos de INST.DE INVEST.MEDICAS
Articulos de INST.DE INVEST.MEDICAS
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Rubio, Maria Fernanda; Werbajh, Santiago Enrique; Cafferata, Eduardo Gustavo Alfredo; Quaglino, Ana; Colo, Georgina Pamela; et al.; TNF-α enhances estrogen-induced cell proliferation of estrogen-dependent breast tumor cells through a complex containing nuclear factor-kappa B; Nature Publishing Group; Oncogene; 25; 9; 3-2006; 1367-1377
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