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dc.contributor.author
Pandey, Abhijeet  
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Nikam, Ajinkya Nitin  
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Padya, Bharath Singh  
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Kulkarni, Sanjay  
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Fernandes, Gasper  
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Shreya, Ajjappla Basavaraj  
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García, Mónica Cristina  
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Caro, Carlos  
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Páez Muñoz, Jose Maria  
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Dhas, Namdev  
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García Martín, Maria Luisa  
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Mehta, Tejal  
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Mutalik, Srinivas  
dc.date.available
2022-12-26T17:46:23Z  
dc.date.issued
2021-05  
dc.identifier.citation
Pandey, Abhijeet; Nikam, Ajinkya Nitin; Padya, Bharath Singh; Kulkarni, Sanjay; Fernandes, Gasper; et al.; Surface architectured black phosphorous nanoconstructs based smart and versatile platform for cancer theranostics; Elsevier Science SA; Coordination Chemistry Reviews; 435; 5-2021; 1-34  
dc.identifier.issn
0010-8545  
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http://hdl.handle.net/11336/182351  
dc.description.abstract
Black Phosphorous has recently gained the attention in the field of 2D nanomaterials owing to its exceptional structure and properties. Specifically, its features like drug loading efficiency, biocompatibility, optical, mechanical, electrical, thermal and phototherapeutic properties contribute to its rising demand as potential alternative to the graphene-based 2D nanomaterials in biomedical applications. Though the BP's outlook appears promising, its practical applicability is highly challenging. In this review we have discussed the different strategies for synthesis of BP and then briefed its unique properties which renders it a potential platform for the biomedical application. We then discuss the importance of heterogeneous doping on improving the stability of BP against chemical degradation and enhancing its photoelectric properties. Meanwhile, BP-based nanoconjugates, stimuli responsive nanoplatforms, therapeutic, imaging and biosensing platforms are the domains of special and comprehensive interest for versatile biomedical applications of BP. The physicochemical interactions at the nano-bio interface like protein corona formation on the surface on nanoparticles due to interaction with the plasma proteins and others play a crucial role in the biological effects of BP. Hence, we have also discussed the recent studies on interactions between Black phosphorus based nanoconstructs with various biological molecules. Further, it is vital to consider the fact that, though biocompatible, BP-nanomaterials can induce inflammatory responses and exhibit toxicity in dose and time dependant manner. Therefore, we have briefed the biodegradation and toxicological aspects of BP to enlighten the readers about the safety and toxicity of black phosphorous. The future developments of this 2D nanomaterial will not only serve as a boon for oncology, but also functions as a potential nanoplatform for other biomedical applications.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science SA  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
2D MATERIALS  
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CANCER THERAPY  
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NANO-BIO-INTERACTION  
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SUBCELLULAR TARGETING  
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SURFACE ARCHITECTURE  
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THERANOSTIC  
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Otras Nanotecnología  
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Nanotecnología  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Surface architectured black phosphorous nanoconstructs based smart and versatile platform for cancer theranostics  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-11-23T11:59:43Z  
dc.identifier.eissn
1873-3840  
dc.journal.volume
435  
dc.journal.pagination
1-34  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Pandey, Abhijeet. Manipal College Of Pharmaceutical Sciences; India  
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Fil: Nikam, Ajinkya Nitin. Manipal College Of Pharmaceutical Sciences; India  
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Fil: Padya, Bharath Singh. Manipal College Of Pharmaceutical Sciences; India  
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Fil: Kulkarni, Sanjay. Manipal College Of Pharmaceutical Sciences; India  
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Fil: Fernandes, Gasper. Manipal College Of Pharmaceutical Sciences; India  
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Fil: Shreya, Ajjappla Basavaraj. Manipal College Of Pharmaceutical Sciences; India  
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Fil: García, Mónica Cristina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina  
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Fil: Caro, Carlos. Universidad de Málaga; España  
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Fil: Páez Muñoz, Jose Maria. Universidad de Málaga; España  
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Fil: Dhas, Namdev. Sres Sanjivani College Of Parmaceutical Education And Research; India. Nirma University. Institute Of Pharmacy; India  
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Fil: García Martín, Maria Luisa. Universidad de Málaga; España  
dc.description.fil
Fil: Mehta, Tejal. Nirma University. Institute Of Pharmacy; India  
dc.description.fil
Fil: Mutalik, Srinivas. Manipal College Of Pharmaceutical Sciences; India  
dc.journal.title
Coordination Chemistry Reviews  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010854521000606  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ccr.2021.213826