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Artículo

Autophagy-Mediated Exosomes as Immunomodulators of Natural Killer Cells in Pancreatic Cancer Microenvironment

Papademetrio, Daniela LauraIcon ; Garcia, Maria NoeIcon ; Grasso, Daniel HectorIcon ; Alvarez, Elida Ester
Fecha de publicación: 02/2021
Editorial: Frontiers Media
Revista: Frontiers in Oncology
e-ISSN: 2234-943X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Pancreas ductal adenocarcinoma is a highly aggressive cancer with an incredible poor lifespan. Different chemotherapeutic agents’ schemes have been tested along the years without significant success. Furthermore, immunotherapy also fails to cope with the disease, even in combination with other standard approaches. Autophagy stands out as a chemoresistance mechanism and is also becoming relevant as responsible for the inefficacy of immunotherapy. In this complex scenario, exosomes have emerged as a new key player in tumor environment. Exosomes act as messengers among tumor cells, including tumor microenvironment immune cells. For instance, tumor-derived exosomes are capable of generating a tolerogenic microenvironment, which in turns conditions the immune system behavior. But also, immune cells-derived exosomes, under non-tolerogenic conditions, induce tumor suppression, although they are able to promote chemoresistance. In that way, NK cells are well known key regulators of carcinogenesis and the inhibition of their function is detrimental for tumor suppression. Additionally, increasing evidence suggests a crosstalk between exosome biogenesis and the autophagy pathway. This mini review has the intention to summarize the available data in the complex relationships between the autophagy pathway and the broad spectrum of exosomes subpopulations in pancreatic cancer, with focus on the NK cells response.
Palabras clave: AUTOPHAGY , EXOSOMES , NATURAL KILLER CELLS , PANCREATIC CANCER , TUMOR MICROENVIRONMENT
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/182254
URL: https://www.frontiersin.org/articles/10.3389/fonc.2020.622956/full
DOI: https://doi.org/10.3389/fonc.2020.622956
Colecciones
Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI
Citación
Papademetrio, Daniela Laura; Garcia, Maria Noe; Grasso, Daniel Hector; Alvarez, Elida Ester; Autophagy-Mediated Exosomes as Immunomodulators of Natural Killer Cells in Pancreatic Cancer Microenvironment; Frontiers Media; Frontiers in Oncology; 10; 622956; 2-2021; 1-9
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