Artículo
Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition
Doncic, Andreas; Atay, Oguzhan; Valk, Ervin; Grande, Alicia Viviana
; Bush, Alan
; Vasen, Gustavo
; Colman Lerner, Alejandro Ariel
; Loog, Mart; Skotheim, Jan M.
Fecha de publicación:
03/2015
Editorial:
Cell Press
Revista:
Cell
ISSN:
0092-8674
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loops in the regulatory network. While positive feedback loops are good at promoting switch-like transitions, they are not expected to retain information to inform subsequent decisions. However, this expectation is based on our current understanding of network motifs that accounts for temporal, but not spatial, dynamics. Here, we show how spatial organization of the feedback-driven yeast G1/S switch enables the transmission of memory of past pheromone exposure across this transition. We expect this to be one of many examples where the exquisite spatial organization of the eukaryotic cell enables previously well-characterized network motifs to perform new and unexpected signal processing functions.
Palabras clave:
Compartmentalization
,
Bistable Switch
,
Far1
,
cell cycle
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Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Citación
Doncic, Andreas; Atay, Oguzhan; Valk, Ervin; Grande, Alicia Viviana; Bush, Alan; et al.; Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition; Cell Press; Cell; 160; 6; 3-2015; 1182-1195
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