Artículo
Renal Damage During Continuous Versus Intermittent Treatment with Lithium
Ossani, Georgina Paula
; Uceda, Ana Margarita; Ponzo, Osvaldo Juan; Lago, Néstor R.; Martino, Diego Javier
Fecha de publicación:
11/2020
Editorial:
Springer
Revista:
Biological Trace Element Research
ISSN:
0163-4984
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of this study was to evaluate renal damage in animals treated with lithium continuously versus intermittently. Rats were randomized into three groups: control group fed ad libitum powered standard diet for 3 months and two experimental groups, one of them fed ad libitum the same diet or the same diet supplemented with 60 mmol of lithium/kg diet every alternate week, for 3 months and the other fed ad libitum powered standard diet for one and a half month and the same diet supplemented with 60 mmol of lithium/kg diet for the last month and a half. Lithemias in experimental groups were within therapeutic range used in humans. At the end of the protocol, diuresis was higher in experimental groups compared to control group. There was no difference in serum creatinine and creatinine clearance. Both experimental groups showed hypertrophy, hyperplasia, and dilatation of cortical collecting tubules although dilatation was greater in continuous group. Longer studies are necessary to clarify the evolution of renal damage. Our preliminary study shows that histopathological damage associated with the use of lithium occurs during both continuous and intermittent treatment, but it seems to be somewhat greater in the continuous group.
Palabras clave:
DOSING REGIMEN
,
HISTOPATHOLOGY
,
KIDNEY DAMAGE
,
LITHIUM
Archivos asociados
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Identificadores
Colecciones
Articulos(INCYT)
Articulos de INSTITUTO DE NEUROCIENCIAS COGNITIVAS Y TRASLACIONAL
Articulos de INSTITUTO DE NEUROCIENCIAS COGNITIVAS Y TRASLACIONAL
Citación
Ossani, Georgina Paula; Uceda, Ana Margarita; Ponzo, Osvaldo Juan; Lago, Néstor R.; Martino, Diego Javier; Renal Damage During Continuous Versus Intermittent Treatment with Lithium; Springer; Biological Trace Element Research; 199; 9; 11-2020; 3411-3415
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