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Artículo

B cells acquire a unique and differential transcriptomic profile during pregnancy

Valeff, Natalin JimenaIcon ; Muzzio, Damián Oscar; Matzner, Franziska; Dibo, Marcos JavierIcon ; Golchert, Janine; Homuth, Georg; Abba, Martín CarlosIcon ; Zygmunt, Marek; Jensen, Cristian FedericoIcon
Fecha de publicación: 07/2021
Editorial: Academic Press Inc Elsevier Science
Revista: Genomics
ISSN: 0888-7543
e-ISSN: 1089-8646
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Pregnancy alters B cell development and function. B cell activation is initiated by antigens binding to the BCR leading to B cell survival, proliferation, antigen presentation and antibody production. We performed a genome-wide transcriptome profiling of splenic B cells from pregnant (P) and non-pregnant (NP) mice and identified 1136 genes exhibiting differential expression in B cells from P mice (625 up- and 511 down-regulated) compared to NP animals. In silico analysis showed that B cell activation through BCR seems to be lowered during pregnancy. RT-qPCR analysis confirmed these data. Additionally, B cells from pregnant women stimulated in vitro through BCR produced lower levels of inflammatory cytokines compared to non-pregnant women. Our results suggest that B cells acquire a state of hypo-responsiveness during gestation, probably as part of the maternal immune strategy for fetal tolerance but also open new avenues to understand why pregnant women are at highest risk for infections.
Palabras clave: B CELLS , BCR , CYTOKINES , PREGNANCY , TRANSCRIPTOMIC PROFILE
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/182198
URL: https://www.sciencedirect.com/science/article/pii/S0888754321002330
DOI: http://dx.doi.org/10.1016/j.ygeno.2021.06.016
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Valeff, Natalin Jimena; Muzzio, Damián Oscar; Matzner, Franziska; Dibo, Marcos Javier; Golchert, Janine; et al.; B cells acquire a unique and differential transcriptomic profile during pregnancy; Academic Press Inc Elsevier Science; Genomics; 113; 4; 7-2021; 2614-2622
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