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dc.contributor.author Perez Perri, Joel Ignacio
dc.contributor.author Dengler, Verónica L.
dc.contributor.author Audetat, Audrey
dc.contributor.author Pandey, Ahwan
dc.contributor.author Bonner, Elyzabeth A.
dc.contributor.author Urh, Marjeta
dc.contributor.author Mendez, Jacqui
dc.contributor.author Daniels, Danette L.
dc.contributor.author Wappner, Pablo
dc.contributor.author Galbraith, Matthew D.
dc.contributor.author Espinosa, Joaquín M.
dc.date.available 2017-06-14T21:18:13Z
dc.date.issued 2016-06
dc.identifier.citation Perez Perri, Joel Ignacio; Dengler, Verónica L.; Audetat, Audrey; Pandey, Ahwan; Bonner, Elyzabeth A.; et al.; The TIP60 complex is a conserved coactivator of HIF1A; Elsevier; Cell Reports; 16; 1; 6-2016; 37-47
dc.identifier.uri http://hdl.handle.net/11336/18218
dc.description.abstract Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene expression remain poorly understood. We report here a conserved role for the TIP60 complex as a HIF1 transcriptional cofactor in Drosophila and human cells. TIP60 (KAT5) is required for HIF1-dependent gene expression in fly cells and embryos and colorectal cancer cells. HIF1A interacts with and recruits TIP60 to chromatin. TIP60 is dispensable for HIF1A association with its target genes but is required for HIF1A-dependent chromatin modification and RNA polymerase II activation in hypoxia. In human cells, global analysis of HIF1A-dependent gene activity reveals that most HIF1A targets require either TIP60, the CDK8-Mediator complex, or both as coactivators for full expression in hypoxia. Thus, HIF1A employs functionally diverse cofactors to regulate different subsets of genes within its transcriptional program.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Hypoxia Inducible Factor
dc.subject Acetyl transferase
dc.subject Transcription
dc.subject Histone
dc.subject.classification Bioquímica y Biología Molecular
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title The TIP60 complex is a conserved coactivator of HIF1A
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-06-12T21:00:11Z
dc.identifier.eissn 2211-1247
dc.journal.volume 16
dc.journal.number 1
dc.journal.pagination 37-47
dc.journal.pais Estados Unidos
dc.description.fil Fil: Perez Perri, Joel Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Dengler, Verónica L.. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil Fil: Audetat, Audrey. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil Fil: Pandey, Ahwan. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil Fil: Bonner, Elyzabeth A.. State University Of Colorado Boulder; Estados Unidos
dc.description.fil Fil: Urh, Marjeta. Promega Corporation; Estados Unidos
dc.description.fil Fil: Mendez, Jacqui. Promega Corporation; Estados Unidos
dc.description.fil Fil: Daniels, Danette L.. Promega Corporation; Estados Unidos
dc.description.fil Fil: Wappner, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil Fil: Galbraith, Matthew D.. Howard Hughes Medical Institute; Estados Unidos
dc.description.fil Fil: Espinosa, Joaquín M.. Howard Hughes Medical Institute; Estados Unidos
dc.journal.title Cell Reports
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S2211124716306957
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.celrep.2016.05.082


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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)