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dc.contributor.author
Solar, Héctor
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dc.contributor.author
Doeyo, Mariana
dc.contributor.author
Ortega, Mariana
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dc.contributor.author
De Barrio, Silvia
dc.contributor.author
Olano, Estela
dc.contributor.author
Moreira, Eduardo
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Buncuga, Martín Gonzalo
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dc.contributor.author
Manzur, Alejandra Marisa
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dc.contributor.author
Crivelli, Adriana
dc.contributor.author
Gondolesi, Gabriel Eduardo
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dc.date.available
2022-12-22T14:27:02Z
dc.date.issued
2021-08
dc.identifier.citation
Solar, Héctor; Doeyo, Mariana; Ortega, Mariana; De Barrio, Silvia; Olano, Estela; et al.; Postsurgical Intestinal Rehabilitation Using Semisynthetic Glucagon-Like Peptide-2 Analogue (sGLP-2) at a Referral Center: Can Patients Achieve Parenteral Nutrition and sGLP-2 Independency?; SAGE Publications; Journal of Parenteral and Enteral Nutrition; 45; 5; 8-2021; 1072-1082
dc.identifier.issn
0148-6071
dc.identifier.uri
http://hdl.handle.net/11336/182166
dc.description.abstract
Background: Teduglutide, a semisynthetic analogue of glucagon-like peptide-2 (sGLP-2), increases intestinal absorption of fluids and nutrients, reducing the need for parenteral nutrition (PN). This report aims to describe our experience with sGLP-2 in a cohort of adult patients with short-bowel syndrome. Methods: This is a prospective observational study on adult patients initially evaluated in our specialized intestinal rehabilitation program that received sGLP-2 from June 2014 to March 2020. Results: Autologous gastrointestinal reconstruction surgery (AGIRS) was performed in 108 patients; 68.5% (74 of 108) achieved intestinal sufficiency with standard medical therapy. Seventeen patients were treated with sGLP-2; 66.5% (8 of 12) received treatment for a mean time of 25.8 weeks (3.4–54.0) and could suspend PN. One patient reinitiated treatment due to renal lithiasis and acute renal failure. Currently, 7 of 12 patients (53.8%) continue without PN for a mean time of 165.6 weeks. Volume, energy, and days of PN were reduced in all patients. No serious adverse events were registered. Four of 7 patients (57.1%) who discontinued PN could also discontinue sGLP-2. Therefore, the use of sGLP-2 increased the overall success rate of PN independency after AGIRS to 76% (82 of 108). Conclusion: This study confirmed that sGLP-2 should be considered as part of the standard therapy for postsurgical medical rehabilitation treatment in patients with chronic intestinal failure. We add to the current knowledge that some patients can discontinue both PN and sGLP-2 in the long term, achieving complete recovery of their quality of life.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SAGE Publications
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GLP2
dc.subject
HOME NUTRITION SUPPORT
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INTESTINAL FAILURE
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PARENTERAL NUTRITION
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REHABILITATION
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SHORT BOWEL SYNDROME
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SURGERY
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TEDUGLUTIDE
dc.subject.classification
Trasplantes
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Postsurgical Intestinal Rehabilitation Using Semisynthetic Glucagon-Like Peptide-2 Analogue (sGLP-2) at a Referral Center: Can Patients Achieve Parenteral Nutrition and sGLP-2 Independency?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-22T00:42:24Z
dc.journal.volume
45
dc.journal.number
5
dc.journal.pagination
1072-1082
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
California
dc.description.fil
Fil: Solar, Héctor. Universidad Favaloro; Argentina
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Fil: Doeyo, Mariana. Universidad Favaloro; Argentina
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Fil: Ortega, Mariana. Universidad Favaloro; Argentina
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Fil: De Barrio, Silvia. Hospital San Martín; Argentina
dc.description.fil
Fil: Olano, Estela. Hospital Maciel; Uruguay
dc.description.fil
Fil: Moreira, Eduardo. Hospital Maciel; Uruguay
dc.description.fil
Fil: Buncuga, Martín Gonzalo. Delta Hospital; Argentina
dc.description.fil
Fil: Manzur, Alejandra Marisa. Gobierno de la Provincia de Mendoza. Hospital Central de Mendoza.; Argentina
dc.description.fil
Fil: Crivelli, Adriana. Universidad Favaloro; Argentina
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Fil: Gondolesi, Gabriel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
dc.journal.title
Journal of Parenteral and Enteral Nutrition
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://aspenjournals.onlinelibrary.wiley.com/doi/10.1002/jpen.1983
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/jpen.1983
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