Artículo
Adjusting the Nèel relaxation time of Fe 3 O 4 /Zn x Co 1-x Fe 2 O 4 core/shell nanoparticles for optimal heat generation in magnetic hyperthermia
Fabris, Fernando
; Lohr, Javier Hernán
; Lima, Enio Junior
; de Almeida, Adriele Aparecida
; Troiani, Horacio Esteban
; Rodriguez, Luis Miguel
; Vasquez Mansilla, Marcelo
; Aguirre Myriam Haydee; Goya, Gerardo Fabian; Rinaldi, Daniele; Ghirri, Alberto; Peddis, Davide; Fiorani, Dino; Zysler, Roberto Daniel
; de Biasi, Emilio
; Winkler, Elin Lilian
Fecha de publicación:
02/2021
Editorial:
IOP Publishing
Revista:
Nanotechnology
ISSN:
0957-4484
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In this work it is shown a precise way to optimize the heat generation in high viscosity magnetic colloids, by adjusting the Néel relaxation time in core/shell bimagnetic nanoparticles, for magnetic fluid hyperthermia (MFH) applications. To pursue this goal, Fe3O4/Zn x Co1-xFe2O4 core/shell nanoparticles were synthesized with 8.5 nm mean core diameter, encapsulated in a shell of ∼1.1 nm of thickness, where the Zn atomic ratio (Zn/(Zn + Co) at%) changes from 33 to 68 at%. The magnetic measurements are consistent with a rigid interface coupling between the core and shell phases, where the effective magnetic anisotropy systematically decreases when the Zn concentration increases, without a significant change of the saturation magnetization. Experiments of MFH of 0.1 wt% of these particles dispersed in water, in Dulbecco modified Eagles minimal essential medium, and a high viscosity butter oil, result in a large specific loss power (SLP), up to 150 W g-1, when the experiments are performed at 571 kHz and 200 Oe. The SLP was optimized adjusting the shell composition, showing a maximum for intermediate Zn concentration. This study shows a way to maximize the heat generation in viscous media like cytosol, for those biomedical applications that require smaller particle sizes.
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Articulos (UE-INN - NODO BARILOCHE)
Articulos de UNIDAD EJECUTORA INSTITUTO DE NANOCIENCIA Y NANOTECNOLOGIA - NODO BARILOCHE
Articulos de UNIDAD EJECUTORA INSTITUTO DE NANOCIENCIA Y NANOTECNOLOGIA - NODO BARILOCHE
Citación
Fabris, Fernando; Lohr, Javier Hernán; Lima, Enio Junior; de Almeida, Adriele Aparecida; Troiani, Horacio Esteban; et al.; Adjusting the Nèel relaxation time of Fe 3 O 4 /Zn x Co 1-x Fe 2 O 4 core/shell nanoparticles for optimal heat generation in magnetic hyperthermia; IOP Publishing; Nanotechnology; 32; 6; 2-2021; 1-11
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