Artículo
Angiotensin II type 1 receptor is involved in hypertension and vascular alterations caused by environmental toxicant hexachlorobenzene
Romero Caimi, Vanesa Giselle; Gorzalczany, Susana Beatriz; Bonazzola, Patricia
; Deza, Zahira Agustina; Roson, Maria Ines
; Alvarez, Laura; Castilla Lozano, Maria del Rocio
Fecha de publicación:
01/2021
Editorial:
Elsevier
Revista:
Toxicology Reports
ISSN:
2214-7500
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Environmental hexachlorobenzene (HCB) increases blood pressure (BP) in female rats, causing alterations in arterial structure and function. Here we study the role of Angiotensin II receptor type 1 (AT1) in HCB-induced hypertension through the use of AT1 antagonist losartan. HCB-treated male rats showed a 22.7% increase in BP which was prevented by losartan. Losartan blocked HCB-induced changes in arterial morphology (decreased aorta cell number and increased wall thickness). Losartan also prevented HCB-induced alterations in artery relaxation by acetylcholine and nitroprusside but not the reduction in the maximum contraction by phenylephrine. Losartan rescued arterial molecular alterations caused by HCB (i.e. an increase in TGF-β1 and AT1 expression and a decrease in eNOS expression and nitrite levels) and reduced hydrogen sulfide plasma concentration. In conclusion: in this work we demonstrate that AT1 activity is involved in HCB effects on the vascular system leading to hypertension.
Palabras clave:
AORTA
,
AT1
,
HEXACHLOROBENZENE
,
HYPERTENSION
,
LOSARTAN
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos (IATIMET)
Articulos de INSTITUTO ALBERTO C. TAQUINI DE INVESTIGACIONES EN MEDICINA TRASLACIONAL
Articulos de INSTITUTO ALBERTO C. TAQUINI DE INVESTIGACIONES EN MEDICINA TRASLACIONAL
Citación
Romero Caimi, Vanesa Giselle; Gorzalczany, Susana Beatriz; Bonazzola, Patricia; Deza, Zahira Agustina; Roson, Maria Ines; et al.; Angiotensin II type 1 receptor is involved in hypertension and vascular alterations caused by environmental toxicant hexachlorobenzene; Elsevier; Toxicology Reports; 8; 1-2021; 1599-1606
Compartir
Altmétricas