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dc.contributor.author
Wolfel Sánchez, Alexis
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dc.contributor.author
Romero, Marcelo Ricardo
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dc.contributor.author
Alvarez Igarzabal, Cecilia Ines
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dc.contributor.other
Ninago, Mario Daniel
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dc.contributor.other
Lopez, Olivia Valeria
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dc.contributor.other
Horst, María Fernanda
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dc.date.available
2022-12-21T11:40:56Z
dc.date.issued
2021
dc.identifier.citation
Wolfel Sánchez, Alexis; Romero, Marcelo Ricardo; Alvarez Igarzabal, Cecilia Ines; Post-synthesis modification of polymers for the development of functional dynamic covalent hydrogels; Nova Science Publishers; 2021; 11-64
dc.identifier.isbn
978-1-68507-219-3
dc.identifier.uri
http://hdl.handle.net/11336/181888
dc.description.abstract
The development of hydrogels to perform specific functions in complex environments requires a detailed refinement of their physicochemical properties and responsiveness to environmental changes. Accordingly, the conventional hydrogel synthesis methods have found an insurmountable barrier when the achievement of fully-functional structures at different scales is intended.Thus, in response to the growing requirements, post-synthesis modifications appear as essential strategies to achieve the desired characteristics. Due to the impulse provided by these methods, progress has been made in materials engineering to allow the development of smart hydrogels that predictably change their properties in response to environmental stimuli. Consequently, in addition to changes in the swelling behavior, the range of possible intelligent response has tremendously expanded to self-healing capacity, shape memory, the release of a bioactive, and/or on-demand degradation in biological tissues, to name a few.In the last years, the incorporation of reversible covalent bonds, supramolecular bonds, or other types of reversible interactions has prompted the study of the self-healing capacity and the shape memory property. The presence of dynamic/reversible bonds into a hydrogel provides it the particularity to self-repair after mechanical damage. Besides, shape-memory makes it possible to modify the hydrogel morphology through external mechanical forces and temporarily fix the new desired geometry by making use of the reversible bonds. Subsequently, the material can return to its original form applying a specific external stimulus. Furthermore, the growing interest in the biological applications of hydrogels has driven efforts in the adjustment of the mechanical properties by controlling polymer-polymer interactions and the degree and type of cross-linking. Another highly required characteristic is the insertion of functional groups in situ, with low toxicity and in the absence of side reactions. Numerous works aimed to yield macrogels with dynamic covalent bonds, the formation of gels with sol-gel behavior, self-curing properties, and/or shape memory and gelation under adequate physiological conditions. In this context, post-synthesis modifications of polymers to the development of functional dynamic covalent hydrogels are presented in this chapter. The polymer composition is usually selected to allow post-synthetic modification to achieve control over morphology, mechanical and swelling properties, and chemical functionality. Herein, we focused on the obtainment of Schiff base crosslinked dynamic covalent networks as a robust strategy to obtain smart materials by bio-orthogonal reactions. Different presented methodologies constitute useful tools for the development of functional materials that could be applied in various lines of research: from the production of devices for the controlled release of drugs to the development of soft actuators, surface modification, the anchoring of biomolecules in chromatographic supports, among others.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nova Science Publishers
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FUNCTIONAL POLYMERS
dc.subject
POST-SYNTHESIS MODIFICATION OF POLYMERS
dc.subject
FUNCTIONAL HYDROGELS
dc.subject
DYNAMIC/REVERSIBLE BONDS INTO A HYDROGEL
dc.subject
DYNAMIC COVALENT NETWORKS
dc.subject.classification
Físico-Química, Ciencia de los Polímeros, Electroquímica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Post-synthesis modification of polymers for the development of functional dynamic covalent hydrogels
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-09-22T10:25:47Z
dc.journal.pagination
11-64
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Wolfel Sánchez, Alexis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
dc.description.fil
Fil: Romero, Marcelo Ricardo. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
dc.description.fil
Fil: Alvarez Igarzabal, Cecilia Ines. Universidad Nacional de Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://novapublishers.com/shop/the-applications-of-hydrogels/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.52305/ACTC8043
dc.conicet.paginas
44
dc.source.titulo
The Applications of Hydrogels
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