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dc.contributor.author
Pirola, Carlos Jose
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dc.contributor.author
Sookoian, Silvia Cristina
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dc.date.available
2022-12-19T14:58:22Z
dc.date.issued
2021-08
dc.identifier.citation
Pirola, Carlos Jose; Sookoian, Silvia Cristina; PNPLA3 and COVID-19 outcomes: thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system; Wiley Blackwell Publishing, Inc; Liver International; 41; 11; 8-2021; 2801-2804
dc.identifier.issn
1478-3223
dc.identifier.uri
http://hdl.handle.net/11336/181750
dc.description.abstract
Genetic variants associated with the risk of NAFLD and NASH exhibit pleiotropic effects 1, 2. Specifically, the nonsynonymous rs738409 C/G variant in PNPLA3 (patatin-like phospholipase domain-containing protein 3), which encodes I148M protein isoforms with a significant effect on the severity of several liver-related outcomes 3, presents pleiotropic effects on cells that mediate the immune response . Recently, two studies from Europe highlighted the potential involvement of the rs738409 in modifying the severity of COVID-19, including hospitalization and death rate. Grimaudo et al. found an association between the rs738409 G-allele and severe COVID-19 outcomes among patients aged 65 years or less 4. On the other side, Innes et al. reported a striking association analysis between the rs738409 and COVID-19 severity outcomes in 1585 UKB participants 5. The authors found that the rs738409-G allele was independently associated with a reduced risk of COVID-19 hospitalization and mortality; the protective effect remained significant after adjusting for major demographic and disease risk factors, including underlying metabolic and liver co-morbidities 5. In addition, Innes et al. performed a meta-analysis of three independent data sources that explored the potential association between rs738409 and COVID-19. This study included data from the FinnGen study (a population-based biobank comprising 83 patients with COVID-19 hospital admission and 274 SARS-CoV-2 positive patients without hospital admission), the Geisinger Health System (n= 854 subjects of European Ancestry, comprising 165 individuals COVID-19 hospitalization vs 689 SARS-CoV-2 positive patients without hospital admission), and the study of Grimaudo et al. (a total of 383 COVID-19 patients)4. The pooled analysis of the above-mentioned data sources showed that the presumed protective effect of the G- "NASH-risk allele" on the morbidity and mortality of COVID-19 could not be further validated.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights
Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5 AR)
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FATTY LIVER
dc.subject
COVID-19
dc.subject
GENETICS
dc.subject
PNPLA3
dc.subject.classification
Gastroenterología y Hepatología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
PNPLA3 and COVID-19 outcomes: thinking outside the box might explain the biology behind pleiotropic effects of rs738409 on the immune system
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-12-06T11:01:04Z
dc.journal.volume
41
dc.journal.number
11
dc.journal.pagination
2801-2804
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Pirola, Carlos Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Liver International
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/liv.15043
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/liv.15043
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