Mostrar el registro sencillo del ítem
dc.contributor.author
González, Claudio Daniel
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Carro Negueruela, María Paula
dc.contributor.author
Santamarina, Catalina Nicora
dc.contributor.author
Resnik, Roxana
dc.contributor.author
Vaccaro, Maria Ines
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.date.available
2022-12-19T14:37:56Z
dc.date.issued
2021-09
dc.identifier.citation
González, Claudio Daniel; Carro Negueruela, María Paula; Santamarina, Catalina Nicora; Resnik, Roxana; Vaccaro, Maria Ines; Autophagy dysregulation in diabetic kidney disease: From pathophysiology to pharmacological interventions; Multidisciplinary Digital Publishing Institute; Cells; 10; 9; 9-2021; 1-18
dc.identifier.uri
http://hdl.handle.net/11336/181737
dc.description.abstract
Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes mellitus. Several factors are involved in its pathophysiology. At a cellular level, diabetic kidney disease is associated with many structural and functional alterations. Autophagy is a cellular mechanism that transports intracytoplasmic components to lysosomes to preserve cellular function and homeostasis. Autophagy integrity is essential for cell homeostasis, its alteration can drive to cell damage or death. Diabetic kidney disease is associated with profound autophagy dysregulation. Autophagy rate and flux alterations were described in several models of diabetic kidney disease. Some of them are closely linked with disease progression and severity. Some antidiabetic agents have shown significant effects on autophagy. A few of them have also demonstrated to modify disease progression and improved outcomes in affected patients. Other drugs also target autophagy and are being explored for clinical use in patients with diabetic kidney disease. The modulation of autophagy could be relevant for the pharmacological treatment and prevention of this disease in the future. Therefore, this is an evolving area that requires further experimental and clinical research. Here we discuss the relationship between autophagy and Diabetic kidney disease and the potential value of autophagy modulation as a target for pharmacological intervention.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
AUTOPHAGY
dc.subject
DIABETIC KIDNEY DISEASE
dc.subject
GLP1 RECEPTOR AGONISTS
dc.subject
METFORMIN
dc.subject
PHARMACOLOGICAL TREATMENT
dc.subject
PODOCYTES
dc.subject
PROXIMALTUBULAR CELLS
dc.subject
RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITORS (RAASI)
dc.subject
SGLT2 INHIBITORS
dc.subject.classification
Bioquímica y Biología Molecular
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Autophagy dysregulation in diabetic kidney disease: From pathophysiology to pharmacological interventions
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-10-04T17:53:13Z
dc.identifier.eissn
2073-4409
dc.journal.volume
10
dc.journal.number
9
dc.journal.pagination
1-18
dc.journal.pais
Suiza
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Basilea
dc.description.fil
Fil: González, Claudio Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.description.fil
Fil: Carro Negueruela, María Paula. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.description.fil
Fil: Santamarina, Catalina Nicora. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.description.fil
Fil: Resnik, Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Vaccaro, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.journal.title
Cells
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-4409/10/9/2497
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/cells10092497
Archivos asociados