Artículo
Early onset consumption of coca paste associated with executive-attention vulnerability markers linked to caudate-frontal structural and functional abnormalities
de la Fuente de la Torre, Laura Alethia
; Schurmann Vignaga, Sofía; Prado, Pilar; Figueras, Rosario; Lizaso, Lucía; Manes, Facundo Francisco
; Cetkovich Bakmas, Marcelo Gustavo; Tagliazucchi, Enzo Rodolfo
; Torralva, Teresa
Fecha de publicación:
10/2021
Editorial:
Elsevier
Revista:
Drug And Alcohol Dependence
ISSN:
0376-8716
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Coca paste is the most popular form of smoked cocaine (SC) in Latin America and also the most widespread among adolescents in vulnerable sectors of society, thus representing a significant public health concern. Despite evidence suggesting that abnormal executive-attention function is predictive of addiction to stimulant drugs, no study to date has compared clinically relevant neuropsychological (NPS) and physiological variables between individuals with histories of smoked cocaine dependence (SCD) and insufflated cocaine hydrochloride dependence (ICD). In this study we evaluated 25 SCD and 22 ICD subjects matched by poly-consumption profiles, and 25 healthy controls (CTR) matched by age, gender, education, and socioeconomic status. An exhaustive NPS battery was used to assess cognitive domains (attention, executive functions, fluid intelligence, memory, language and social cognition). We complemented this assessment with structural (MRI) and functional (fMRI) neuroimaging data. We found that executive function and attention impairments could be explained by the administration route of cocaine, with strongest impairments for the SCD group. SCD also presented reduced grey matter density relative to ICD and CTR in the bilateral caudate, a key area for executive and attentional function. Functional connectivity between left caudate and inferior frontal regions mediated the association between brain structure and behavioral performance. Our results highlight the relevance of assessing the route of administration of stimulants, both in clinical and research settings.
Palabras clave:
CAUDATE
,
COCAINE
,
EXECUTIVE FUNCTION
,
FMRI
,
FRONTAL CORTEX
,
MRI
,
ROUTE OF ADMINISTRATION
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IFIBA)
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos de INST.DE FISICA DE BUENOS AIRES
Articulos(INCYT)
Articulos de INSTITUTO DE NEUROCIENCIAS COGNITIVAS Y TRASLACIONAL
Articulos de INSTITUTO DE NEUROCIENCIAS COGNITIVAS Y TRASLACIONAL
Citación
de la Fuente de la Torre, Laura Alethia; Schurmann Vignaga, Sofía; Prado, Pilar; Figueras, Rosario; Lizaso, Lucía; et al.; Early onset consumption of coca paste associated with executive-attention vulnerability markers linked to caudate-frontal structural and functional abnormalities; Elsevier; Drug And Alcohol Dependence; 227; 108926; 10-2021; 1-9
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