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dc.contributor.author
Weiss, Lukas  
dc.contributor.author
Jungblut, Lucas David  
dc.contributor.author
Pozzi, Andrea Gabriela  
dc.contributor.author
Zielinski, Barbara S.  
dc.contributor.author
O'Connell, Lauren A.  
dc.contributor.author
Hassenklöver, Thomas  
dc.contributor.author
Manzini, Ivan  
dc.date.available
2022-12-19T10:54:15Z  
dc.date.issued
2020-02  
dc.identifier.citation
Weiss, Lukas; Jungblut, Lucas David; Pozzi, Andrea Gabriela; Zielinski, Barbara S.; O'Connell, Lauren A.; et al.; Multi‐glomerular projection of single olfactory receptor neurons is conserved among amphibians; Wiley-liss, div John Wiley & Sons Inc.; Journal Of Comparative Neurology; 528; 13; 2-2020; 2239-2253  
dc.identifier.issn
0021-9967  
dc.identifier.uri
http://hdl.handle.net/11336/181690  
dc.description.abstract
Individual receptor neurons in the peripheral olfactory organ extend long axons into the olfactory bulb forming synapses with projection neurons in spherical neuropil regions, called glomeruli. Generally, odor map formation and odor processing in all vertebrates is based on the assumption that receptor neuron axons exclusively connect to a single glomerulus without any axonal branching. We comparatively tested this hypothesis in multiple fish and amphibian species (both sexes) by applying sparse cell electroporation to trace single olfactory receptor neuron axons. Sea lamprey (jawless fish) and zebrafish (bony fish) support the unbranched axon concept, with 94% of axons terminating in single glomeruli. Contrastingly, axonal projections of the axolotl (salamander) branch extensively before entering up to six distinct glomeruli. Receptor neuron axons labeled in frog species (Pipidae, Bufonidae, Hylidae, and Dendrobatidae) predominantly bifurcate before entering a glomerulus and 59 and 50% connect to multiple glomeruli in larval and postmetamorphotic animals, respectively. Independent of developmental stage, lifestyle, and adaptations to specific habitats, it seems to be a common feature of amphibian olfactory receptor neuron axons to frequently bifurcate and connect to multiple glomeruli. Our study challenges the unbranched axon concept as a universal vertebrate feature and it is conceivable that also later diverging vertebrates deviate from it. We propose that this unusual wiring logic evolved around the divergence of the terrestrial tetrapod lineage from its aquatic ancestors and could be the basis of an alternative way of odor processing.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ANURA  
dc.subject
AXONAL WIRING  
dc.subject
EVOLUTION  
dc.subject
FISHES  
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GLOMERULI  
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OLFACTION  
dc.subject
SENSORY SYSTEM  
dc.subject.classification
Otros Tópicos Biológicos  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Multi‐glomerular projection of single olfactory receptor neurons is conserved among amphibians  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-09-07T18:30:41Z  
dc.journal.volume
528  
dc.journal.number
13  
dc.journal.pagination
2239-2253  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
New York  
dc.description.fil
Fil: Weiss, Lukas. Justus Liebig Universitat Giessen; Alemania  
dc.description.fil
Fil: Jungblut, Lucas David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina  
dc.description.fil
Fil: Pozzi, Andrea Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina  
dc.description.fil
Fil: Zielinski, Barbara S.. University of Windsor. Great Lakes Institute for Enviromental Research; Canadá  
dc.description.fil
Fil: O'Connell, Lauren A.. University of Stanford; Estados Unidos  
dc.description.fil
Fil: Hassenklöver, Thomas. Justus Liebig Universitat Giessen; Alemania  
dc.description.fil
Fil: Manzini, Ivan. Justus Liebig Universitat Giessen; Alemania  
dc.journal.title
Journal Of Comparative Neurology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.24887  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cne.24887