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dc.contributor.author
Weiss, Lukas
dc.contributor.author
Jungblut, Lucas David
dc.contributor.author
Pozzi, Andrea Gabriela
dc.contributor.author
Zielinski, Barbara S.
dc.contributor.author
O'Connell, Lauren A.
dc.contributor.author
Hassenklöver, Thomas
dc.contributor.author
Manzini, Ivan
dc.date.available
2022-12-19T10:54:15Z
dc.date.issued
2020-02
dc.identifier.citation
Weiss, Lukas; Jungblut, Lucas David; Pozzi, Andrea Gabriela; Zielinski, Barbara S.; O'Connell, Lauren A.; et al.; Multi‐glomerular projection of single olfactory receptor neurons is conserved among amphibians; Wiley-liss, div John Wiley & Sons Inc.; Journal Of Comparative Neurology; 528; 13; 2-2020; 2239-2253
dc.identifier.issn
0021-9967
dc.identifier.uri
http://hdl.handle.net/11336/181690
dc.description.abstract
Individual receptor neurons in the peripheral olfactory organ extend long axons into the olfactory bulb forming synapses with projection neurons in spherical neuropil regions, called glomeruli. Generally, odor map formation and odor processing in all vertebrates is based on the assumption that receptor neuron axons exclusively connect to a single glomerulus without any axonal branching. We comparatively tested this hypothesis in multiple fish and amphibian species (both sexes) by applying sparse cell electroporation to trace single olfactory receptor neuron axons. Sea lamprey (jawless fish) and zebrafish (bony fish) support the unbranched axon concept, with 94% of axons terminating in single glomeruli. Contrastingly, axonal projections of the axolotl (salamander) branch extensively before entering up to six distinct glomeruli. Receptor neuron axons labeled in frog species (Pipidae, Bufonidae, Hylidae, and Dendrobatidae) predominantly bifurcate before entering a glomerulus and 59 and 50% connect to multiple glomeruli in larval and postmetamorphotic animals, respectively. Independent of developmental stage, lifestyle, and adaptations to specific habitats, it seems to be a common feature of amphibian olfactory receptor neuron axons to frequently bifurcate and connect to multiple glomeruli. Our study challenges the unbranched axon concept as a universal vertebrate feature and it is conceivable that also later diverging vertebrates deviate from it. We propose that this unusual wiring logic evolved around the divergence of the terrestrial tetrapod lineage from its aquatic ancestors and could be the basis of an alternative way of odor processing.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley-liss, div John Wiley & Sons Inc.
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANURA
dc.subject
AXONAL WIRING
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EVOLUTION
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FISHES
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GLOMERULI
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OLFACTION
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SENSORY SYSTEM
dc.subject.classification
Otros Tópicos Biológicos
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Multi‐glomerular projection of single olfactory receptor neurons is conserved among amphibians
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-07T18:30:41Z
dc.journal.volume
528
dc.journal.number
13
dc.journal.pagination
2239-2253
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Weiss, Lukas. Justus Liebig Universitat Giessen; Alemania
dc.description.fil
Fil: Jungblut, Lucas David. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
dc.description.fil
Fil: Pozzi, Andrea Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Biodiversidad y Biología Experimental y Aplicada. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Biodiversidad y Biología Experimental y Aplicada; Argentina
dc.description.fil
Fil: Zielinski, Barbara S.. University of Windsor. Great Lakes Institute for Enviromental Research; Canadá
dc.description.fil
Fil: O'Connell, Lauren A.. University of Stanford; Estados Unidos
dc.description.fil
Fil: Hassenklöver, Thomas. Justus Liebig Universitat Giessen; Alemania
dc.description.fil
Fil: Manzini, Ivan. Justus Liebig Universitat Giessen; Alemania
dc.journal.title
Journal Of Comparative Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/cne.24887
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cne.24887
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