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dc.contributor.author
Lima, Beatriz Viviana
dc.contributor.author
Ricci, Maria
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Garro, Adriana
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Juhász, Tünde
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Szigyártó, Imola Csilla
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Papp, Zita I.
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Feresin, Gabriela Egly
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Garcia de la Torre, Jose
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Lopez Cascales, Jose Javier
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Fülöp, Lívia
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Beke-Somfai, Tamás
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Enriz, Ricardo Daniel
dc.date.available
2022-12-17T02:51:47Z
dc.date.issued
2021-10
dc.identifier.citation
Lima, Beatriz Viviana; Ricci, Maria; Garro, Adriana; Juhász, Tünde; Szigyártó, Imola Csilla; et al.; New short cationic antibacterial peptides. Synthesis, biological activity and mechanism of action; Elsevier Science; Biochimica et Biophysica Acta - Biomembranes; 1863; 10; 10-2021; 1-13
dc.identifier.issn
0005-2736
dc.identifier.uri
http://hdl.handle.net/11336/181663
dc.description.abstract
We report a theoretical and experimental study on a new series of small-sized antibacterial peptides. Synthesis and bioassays for these peptides are reported here. In addition, we evaluated different physicochemical parameters that modulate antimicrobial activity (charge, secondary structure, amphipathicity, hydrophobicity and polarity). We also performed molecular dynamic simulations to assess the interaction between these peptides and their molecular target (the membrane). Biophysical characterization of the peptides was carried out with different techniques, such as circular dichroism (CD), linear dichroism (LD), infrared spectroscopy (IR), dynamic light scattering (DLS), fluorescence spectroscopy and TEM studies using model systems (liposomes) for mammalian and bacterial membranes. The results of this study allow us to draw important conclusions on three different aspects. Theoretical and experimental results indicate that small-sized peptides have a particular mechanism of action that is different to that of large peptides. These results provide additional support for a previously proposed four-step mechanism of action. The possible pharmacophoric requirement for these small-sized peptides is discussed. Furthermore, our results indicate that a net +4 charge is the adequate for 9 amino acid long peptides to produce antibacterial activity. The information reported here is very important for designing new antibacterial peptides with these structural characteristics.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTIMICROBIAL PEPTIDES
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MECHANISM OF ACTION
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PEPTIDE BIOPHYSICAL CHARACTERIZATION
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SMALL-SIZED PEPTIDES
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
New short cationic antibacterial peptides. Synthesis, biological activity and mechanism of action
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-13T14:53:32Z
dc.journal.volume
1863
dc.journal.number
10
dc.journal.pagination
1-13
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Lima, Beatriz Viviana. Universidad Nacional de San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
dc.description.fil
Fil: Ricci, Maria. Természettudományi Kutatóközpont; Hungría
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Fil: Garro, Adriana. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.description.fil
Fil: Juhász, Tünde. Természettudományi Kutatóközpont; Hungría
dc.description.fil
Fil: Szigyártó, Imola Csilla. Természettudományi Kutatóközpont; Hungría
dc.description.fil
Fil: Papp, Zita I.. Szegedi Tudományegyetem; Hungría
dc.description.fil
Fil: Feresin, Gabriela Egly. Universidad Nacional de San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
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Fil: Garcia de la Torre, Jose. Universidad de Murcia; España
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Fil: Lopez Cascales, Jose Javier. Universidad Politécnica de Cartagena; España
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Fil: Fülöp, Lívia. Szegedi Tudományegyetem; Hungría
dc.description.fil
Fil: Beke-Somfai, Tamás. Természettudományi Kutatóközpont; Hungría
dc.description.fil
Fil: Enriz, Ricardo Daniel. Universidad Nacional de San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
dc.journal.title
Biochimica et Biophysica Acta - Biomembranes
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbamem.2021.183665
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0005273621001152
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