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dc.contributor.author
Singer, Phillipp
dc.contributor.author
Hauser, Jonas
dc.contributor.author
Lopez Llano, Luis
dc.contributor.author
Peleg Raibstein, Daria
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Feldon, Joram
dc.contributor.author
Gargiulo, Pascual Angel
dc.contributor.author
Yee, Benjamin K.
dc.date.available
2017-06-14T17:58:10Z
dc.date.issued
2013-01
dc.identifier.citation
Singer, Phillipp; Hauser, Jonas; Lopez Llano, Luis; Peleg Raibstein, Daria; Feldon, Joram; et al.; Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice; Elsevier Science; Behavioural Brain Research; 242; 1-2013; 166-177
dc.identifier.issn
0166-4328
dc.identifier.uri
http://hdl.handle.net/11336/18163
dc.description.abstract
Prepulse inhibition (PPI) of the acoustic startle reflex refers to the attenuation of the startle response to an intense pulse stimulus when it is shortly preceded by a weak non-startling prepulse stimulus. It is a well-established high-throughput translational measure of pre-attentive sensory gating, and its impairment is detected in several neuropsychiatric diseases including schizophrenia. It has been hypothesized that PPI might be associated with, or predictive of, cognitive deficiency in such diseases, and therefore provide an efficient assay for screening drugs with potential pro-cognitive efficacy. Free from any predetermined disease models, the present study evaluated in a homogeneous cohort of inbred C57BL/6 mice the presence of a statistical link between PPI expression and cognitive performance. Performance indices in a spatial reference memory test and a working memory test conducted in the Morris water maze, and contextual fear conditioning were correlated against pre-existing baseline PPI expression. A specific correlative link between working memory and PPI induced by weak (but not strong) prepulse was revealed. In addition, a correlation between habituation of the startle reflex and reference memory was identified for the first time: a stronger overt habituation effect was associated with superior spatial search accuracy. The PPI paradigm thus provides two independent predictors of dissociable cognitive traits in normal C57BL/6 mice; and they might serve as potential markers for high-throughput evaluation of potential cognitive enhancers, especially in the context of schizophrenia where deficits in startle habituation and PPI co-exist.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Pre-Pulse
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Inhibition
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Cognition
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Schizophrenia
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Correlation
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Individual Difference
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Learning
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Prepulse Inhibition
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Sensorinotor Gating
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Prepulse inhibition predicts working memory performance while startle habituation predicts spatial reference memory retention in C57BL/6 mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-09-19T18:46:52Z
dc.journal.volume
242
dc.journal.pagination
166-177
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Singer, Phillipp. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
dc.description.fil
Fil: Hauser, Jonas. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
dc.description.fil
Fil: Lopez Llano, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Peleg Raibstein, Daria. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
dc.description.fil
Fil: Feldon, Joram. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
dc.description.fil
Fil: Gargiulo, Pascual Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
dc.description.fil
Fil: Yee, Benjamin K.. Swiss Federal Institute of Technology. Laboratory of Behavioural Neurobiology; Suiza
dc.journal.title
Behavioural Brain Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbr.2012.12.011
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0166432812007930
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