Artículo
Galectin-8: a matricellular lectin with key roles in angiogenesis
Troncoso, María Fernanda
; Ferragut, Fátima; Bacigalupo, Maria Lorena
; Cardenas Delgado, Victor Manuel
; Nugnes, Lorena Gisela
; Gentilini, Lucas Daniel
; Laderach, Diego Jose
; Wolfenstein, Carlota Elisa
; Compagno, Daniel Georges
; Rabinovich, Gabriel Adrián
; Elola, Maria Teresa
Fecha de publicación:
10/2014
Editorial:
Oxford University Press
Revista:
Glycobiology
ISSN:
0959-6658
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Galectin-8 (gal-8) is a “tandem-repeat”-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis.
Palabras clave:
Galectin-8
,
Angiogenesis
,
Endothelium
,
Cd166
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IQUIBICEN)
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos de INSTITUTO DE QUIMICA BIOLOGICA DE LA FACULTAD DE CS. EXACTAS Y NATURALES
Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Troncoso, María Fernanda; Ferragut, Fátima; Bacigalupo, Maria Lorena; Cardenas Delgado, Victor Manuel; Nugnes, Lorena Gisela; et al.; Galectin-8: a matricellular lectin with key roles in angiogenesis; Oxford University Press; Glycobiology; 24; 10; 10-2014; 907-914
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