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dc.contributor.author
Bertera, Facundo Martin

dc.contributor.author
del Mauro, Julieta Sofía

dc.contributor.author
Lovera, Valeria

dc.contributor.author
Chiappetta, Diego Andrés

dc.contributor.author
Polizio, Ariel Héctor

dc.contributor.author
Taira, Carlos Alberto

dc.contributor.author
Höcht, Christian

dc.date.available
2017-06-13T19:07:36Z
dc.date.issued
2014-03
dc.identifier.citation
Bertera, Facundo Martin; del Mauro, Julieta Sofía; Lovera, Valeria; Chiappetta, Diego Andrés; Polizio, Ariel Héctor; et al.; Enantioselective pharmacokinetics and cardiovascular effects of nebivolol in L-NAME hypertensive rats; Nature Publishing Group; Hypertension Research; 37; 3; 3-2014; 194-201
dc.identifier.issn
0916-9636
dc.identifier.uri
http://hdl.handle.net/11336/18124
dc.description.abstract
The cardiovascular effects and pharmacokinetics of nebivolol were assessed in N(G)-nitro-l-arginine methyl ester (L-NAME) hypertensive and normotensive control rats. Male Wistar rats were randomly divided to drink tap water (control) or L-NAME solution for 2 weeks. The effects of nebivolol (3 or 10 mg kg−1 i.v.) on blood pressure (BP), heart rate and BP variability (BPV) were recorded in awake L-NAME and control rats. Short-term and beat-to-beat BPV was assessed by the s.d. and spectral analysis of the BP recordings. Nebivolol pharmacokinetics was studied by means of traditional blood sampling. Nebivolol showed enantioselective pharmacokinetics in both experimental groups; the clearance and the volume of distribution of l-nebivolol were significantly greater than those of the d-enantiomer. The hypotensive response to nebivolol was significantly enhanced in L-NAME rats (Δmean arterial pressure (MAP): −16.1±1.1%, P<0.05 vs. control rats) compared with normotensive animals (ΔMAP: −1.4±2.1%). An analysis of the beat-to-beat BPV showed a greater reduction in VLF BPV in the L-NAME compare with the control rats. Nebivolol significantly reduced the low-frequency/high-frequency ratio in hypertensive L-NAME animals compared with normotensive rats. Short-term BPV was markedly reduced by nebivolol in both experimental groups, although the attenuation of the s.d. of BP recording was greater in L-NAME rats. In conclusion, the hypotensive efficacy of nebivolol is significantly enhanced in L-NAME rats compared with normotensive animals, which is most likely due to a greater reduction in vascular sympathetic activity. Nebivolol markedly attenuated short-term BPV in both experimental groups, suggesting that β-blockers with additional pharmacological actions provide beneficial cardiovascular effects by controlling high BP and its short-term variability.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group

dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Blood Pressure Variability
dc.subject
Enantioselective Pharmacokinetics
dc.subject
L-Name Hypertension
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Nebivolol
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Spectral Analysis
dc.subject.classification
Patología

dc.subject.classification
Medicina Básica

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CIENCIAS MÉDICAS Y DE LA SALUD

dc.title
Enantioselective pharmacokinetics and cardiovascular effects of nebivolol in L-NAME hypertensive rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-19T18:13:34Z
dc.journal.volume
37
dc.journal.number
3
dc.journal.pagination
194-201
dc.journal.pais
Reino Unido

dc.journal.ciudad
Londres
dc.description.fil
Fil: Bertera, Facundo Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.description.fil
Fil: del Mauro, Julieta Sofía. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Lovera, Valeria. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.description.fil
Fil: Chiappetta, Diego Andrés. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Polizio, Ariel Héctor. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Taira, Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Höcht, Christian. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología; Argentina
dc.journal.title
Hypertension Research

dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/hr/journal/v37/n3/full/hr2013140a.html
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/hr.2013.140
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