Heterogeneity across neural populations: Its significance for the dynamics and functions of neural circuits

Abstract

Neural populations show patterns of synchronous activity, as they share common correlated inputs. Neurons in the cortex that are connected by strong synapses cause rapid firing explosions. In addition, areas that are connected by weaker synapses have a slower dynamics and they can contribute to asymmetries in the input distributions. The aim of this work is to develop a neural model to investigate how the heterogeneities in the synaptic input distributions affect different levels of organizational activity in the brain dynamics. We analytically show how small changes in the correlation inputs can cause large changes in the interactions of the outputs that lead to a phase transition, demonstrating that a simple variation in the direction of a biased skewed distribution in the neuronal inputs can generate a transition of states in the firing rate, passing from spontaneous silence ("down state") to an absolute spiking activity ("up state"). We present an exact quantification of the dynamics of the output variables, showing that when considering a biased skewed distribution in the inputs of neuronal population, the critical point is not in an asynchronous or synchronous state but rather at an intermediate value.