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Artículo

Maternal ancestry and hematological cancer risk: Case-control study in an Argentinean population

Cerliani, María BelénIcon ; Mayordomo, Andrea ConstanzaIcon ; Sanchez Dova, Anaclara; Soarez, Julieta Natalia; Fuhr Etcheverry, JosefinaIcon ; Piñero, Tamara AlejandraIcon ; Cajal, Andrea; Jauk, Federico; Garcia Rivello, Hernan Jorge; Vaccaro, Carlos Alberto; Richard, Silvina MarielIcon ; Bravi, Claudio MarceloIcon ; Pavicic, Walter HernanIcon
Fecha de publicación: 05/2021
Editorial: Future Medicine
Revista: Personalized Medicine
ISSN: 1741-0541
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Genética y Herencia

Resumen

Aim: We investigated the role of maternal ancestry in neoplastic hematological malignancies (HMs) risk in a population from Central Argentina. Materials & methods: We analyzed 125 cases with HMs and 310 controls from a public hospital, and a set of 202 colorectal, breast, lung, and hematologic cancer patients from a private hospital. Results: A decreased risk for HMs was associated with the Native American haplogroup B2 (odds ratio = 0.49; 95% CI: 0.25-0.92; p = 0.02). The sub-Saharan African parahaplogroup L was associated with higher susceptibility for disease (odds ratio = 3.10; 95% CI: 1.04-9.31; p = 0.043). Although the mean ancestral proportions in the total studied population was as published (61.7% Native American, 34.6% European and 3.7% African), an unequal distribution was observed between hospitals. Conclusion: We confirmed the tri-hybrid nature of the Argentinean population, with proportions varying within the country. Our finding supports the notion that associated haplogroup is population and cancer specific.
Palabras clave: ARGENTINA , CANCER RISK , CASE-CONTROL STUDY , GENETIC DIVERSITY , GENETIC MARKERS , HAPLOGROUP , MATERNAL ANCESTRY , MITOCHONDRIAL DNA , NATIVE AMERICAN , NEOPLASTIC HEMATOLOGICAL MALIGNANCIES
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/181195
DOI: https://doi.org/10.2217/pme-2020-0062
URL: https://www.futuremedicine.com/doi/10.2217/pme-2020-0062
Colecciones
Articulos (IMTIB)
Articulos de INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Cerliani, María Belén; Mayordomo, Andrea Constanza; Sanchez Dova, Anaclara; Soarez, Julieta Natalia; Fuhr Etcheverry, Josefina; et al.; Maternal ancestry and hematological cancer risk: Case-control study in an Argentinean population; Future Medicine; Personalized Medicine; 18; 3; 5-2021; 269-281
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