Artículo
Maternal ancestry and hematological cancer risk: Case-control study in an Argentinean population
Cerliani, María Belén
; Mayordomo, Andrea Constanza
; Sanchez Dova, Anaclara; Soarez, Julieta Natalia; Fuhr Etcheverry, Josefina
; Piñero, Tamara Alejandra
; Cajal, Andrea; Jauk, Federico; Garcia Rivello, Hernan Jorge; Vaccaro, Carlos Alberto; Richard, Silvina Mariel
; Bravi, Claudio Marcelo
; Pavicic, Walter Hernan
Fecha de publicación:
05/2021
Editorial:
Future Medicine
Revista:
Personalized Medicine
ISSN:
1741-0541
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Aim: We investigated the role of maternal ancestry in neoplastic hematological malignancies (HMs) risk in a population from Central Argentina. Materials & methods: We analyzed 125 cases with HMs and 310 controls from a public hospital, and a set of 202 colorectal, breast, lung, and hematologic cancer patients from a private hospital. Results: A decreased risk for HMs was associated with the Native American haplogroup B2 (odds ratio = 0.49; 95% CI: 0.25-0.92; p = 0.02). The sub-Saharan African parahaplogroup L was associated with higher susceptibility for disease (odds ratio = 3.10; 95% CI: 1.04-9.31; p = 0.043). Although the mean ancestral proportions in the total studied population was as published (61.7% Native American, 34.6% European and 3.7% African), an unequal distribution was observed between hospitals. Conclusion: We confirmed the tri-hybrid nature of the Argentinean population, with proportions varying within the country. Our finding supports the notion that associated haplogroup is population and cancer specific.
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Colecciones
Articulos (IMTIB)
Articulos de INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Articulos de INSTITUTO DE MEDICINA TRASLACIONAL E INGENIERIA BIOMEDICA
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Cerliani, María Belén; Mayordomo, Andrea Constanza; Sanchez Dova, Anaclara; Soarez, Julieta Natalia; Fuhr Etcheverry, Josefina; et al.; Maternal ancestry and hematological cancer risk: Case-control study in an Argentinean population; Future Medicine; Personalized Medicine; 18; 3; 5-2021; 269-281
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