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dc.contributor.author
Levín, Pedro
dc.contributor.author
Balsa, Lucia Mariana
dc.contributor.author
Silva, Carlos P.
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Herzog, Austin E.
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Vega, Andrés
dc.contributor.author
Pavez, Jorge
dc.contributor.author
Leon, Ignacio Esteban
dc.contributor.author
Lemus, Luis
dc.date.available
2022-12-13T17:45:53Z
dc.date.issued
2021-09
dc.identifier.citation
Levín, Pedro; Balsa, Lucia Mariana; Silva, Carlos P.; Herzog, Austin E.; Vega, Andrés; et al.; Artificial chemical nuclease and cytotoxic activity of a mononuclear copper(I) complex and a related binuclear double-stranded helicate; Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2021; 39; 9-2021; 4103-4112
dc.identifier.issn
1434-1948
dc.identifier.uri
http://hdl.handle.net/11336/181043
dc.description.abstract
Copper complexes are promising candidates for anticancer drugs, because of their redox properties and the ability to generate ROS (reactive oxygen species) in the cellular media. Most of the reported complexes with anticancer properties are based on Cu(II), which must be reduced to Cu(I) to exert the therapeutic action. Here, we report on the synthesis and characterization of two novel copper(I) complexes, a mononuclear complex [Cu(L1)2](ClO4) (1) and a binuclear helicate [Cu2(L2)2](ClO4)2 (2) (L1=2-ethoxy-1,10-phenanthroline, L2=1,2-bis((1,10-phenanthrolin-2-yl)oxy)ethane), which were designed to be structurally comparable, in order to evaluate the effect of nuclearity on the artificial nuclease activity. The activity of helicate (2) was higher than that of the monometallic (1), and the DNA cleavage mechanism is through the generation of hydroxyl radical in a Fenton-like reaction, which occurs after oxidation of Cu(I) by O2. Also, helicate (2) showed a higher cytotoxic effect against different cancer cells lines, while both complexes are more active than cisplatin.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley VCH Verlag
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTICANCER ACTIVITY
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ARTIFICIAL NUCLEASES
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COPPER
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HYDROXYL RADICALS
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STRUCTURE ELUCIDATION
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Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Artificial chemical nuclease and cytotoxic activity of a mononuclear copper(I) complex and a related binuclear double-stranded helicate
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T23:57:35Z
dc.journal.volume
2021
dc.journal.number
39
dc.journal.pagination
4103-4112
dc.journal.pais
Alemania
dc.journal.ciudad
Weinheim
dc.description.fil
Fil: Levín, Pedro. Universidad de Santiago de Chile; Chile
dc.description.fil
Fil: Balsa, Lucia Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Silva, Carlos P.. Universidad de Santiago de Chile; Chile
dc.description.fil
Fil: Herzog, Austin E.. University Johns Hopkins; Estados Unidos
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Fil: Vega, Andrés. Universidad Andrés Bello; Chile. Centro para el Desarrollo de Nanociencias y Nanotecnología; Chile
dc.description.fil
Fil: Pavez, Jorge. Universidad de Santiago de Chile; Chile. Soft Matter Research and Technology Center; Chile
dc.description.fil
Fil: Leon, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
dc.description.fil
Fil: Lemus, Luis. Universidad de Santiago de Chile; Chile
dc.journal.title
European Journal of Inorganic Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/ejic.202100673
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ejic.202100673
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