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dc.contributor.author
Viaña Mendieta, Pamela
dc.contributor.author
Sanchez, Mirna Lorena
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dc.contributor.author
Benavides, Jorge
dc.date.available
2022-12-13T14:33:07Z
dc.date.issued
2022-01
dc.identifier.citation
Viaña Mendieta, Pamela; Sanchez, Mirna Lorena; Benavides, Jorge; Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants; John Wiley & Sons; International Wound Journal; 19; 1; 1-2022; 100-113
dc.identifier.issn
1742-4801
dc.identifier.uri
http://hdl.handle.net/11336/180969
dc.description.abstract
Wound healing is a complex process of communication between growth factors, reactive species of oxygen, cells, signalling pathways, and cytokines in the extracellular matrix, in which growth factors are the key regulators. In humans, the main regulators of the cellular responses in wound healing are five growth factors, namely EGF, bFGF, VEGF, and TGF-β1. On the other hand, antioxidants such as astaxanthin, beta-carotene, epigallocatechin gallate, delphinidin, and curcumin have been demonstrated to stimulate cell proliferation, migration and angiogenesis, and control inflammation, to suggest a practical approach to design new strategies to treat non-healing cutaneous conditions. Based on the individual effects of growth factors and antioxidants, it may be envisioned that the use of both types of bioactives in wound healing formulations may have an additive or synergistic effect on the healing potential. This review addresses the effect of growth factors and antioxidants on wound healing-related processes. Furthermore, a prospective on their potential additive or synergistic effect on wound healing formulations, based on their individual effects, is presented. This may serve as a guide for the development of a new generation of wound healing formulations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
ANTIOXIDANTS
dc.subject
GROWTH FACTORS
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SIGNALLING PATHWAY
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WOUND HEALING
dc.subject.classification
Tecnologías que involucran la manipulación de células, tejidos, órganos o todo el organismo
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dc.subject.classification
Biotecnología de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Rational selection of bioactive principles for wound healing applications: Growth factors and antioxidants
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T16:55:37Z
dc.identifier.eissn
1742-481X
dc.journal.volume
19
dc.journal.number
1
dc.journal.pagination
100-113
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Viaña Mendieta, Pamela. Instituto Tecnológico de Monterrey; México
dc.description.fil
Fil: Sanchez, Mirna Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
dc.description.fil
Fil: Benavides, Jorge. Instituto Tecnológico de Monterrey; México
dc.journal.title
International Wound Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/iwj.13602
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/iwj.13602
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