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dc.contributor.author
Rivera Hernández, Gabriela
dc.contributor.author
Antunes Ricardo, Marilena
dc.contributor.author
Martínez Morales, Patricia
dc.contributor.author
Sanchez, Mirna Lorena
dc.date.available
2022-12-13T13:47:21Z
dc.date.issued
2021-05
dc.identifier.citation
Rivera Hernández, Gabriela; Antunes Ricardo, Marilena; Martínez Morales, Patricia; Sanchez, Mirna Lorena; Polyvinyl alcohol based-drug delivery systems for cancer treatment; Elsevier Science; International Journal Of Pharmaceutics; 600; 5-2021; 1-11
dc.identifier.issn
0378-5173
dc.identifier.uri
http://hdl.handle.net/11336/180959
dc.description.abstract
Polyvinyl alcohol (PVA) is a biodegradable semicrystalline synthetic polymer that has been used for biomedical applications for several years. In the pharmaceutical area, PVA has been widely used to prepare solid dispersions to improve the solubility of drugs. Furthermore, it has been demonstrated that PVA is highly biocompatible and non-toxic in in-vitro and in-vivo studies. Several reports provided in this review suggest a promising strategy for cancer treatment. Thus far, the current therapy includes a combination of surgery, chemotherapy, and radiotherapy, the effectivity can be limited due to the heterogeneous manifestations of the disease, dose-related toxicity, and side effects. A promising strategy is the implementation of a targeted therapy using hydrogels, microparticles, or nanoparticles (NPs), capable of encapsulating, protecting, transporting, and targeted administration of a therapeutic agent. Considering the relevance of the PVA in conjunction with their copolymers, it has become a promising biodegradable material to build novel functional composites used in the fabrication of hydrogels, microparticles, nanoparticles, and nanocomposites for drug delivery systems in cancer treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CANCER
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HYDROGEL
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MICROPARTICLES
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NANOPARTICLE
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POLYVINYL ALCOHOL
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Ingeniería de los Materiales
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Polyvinyl alcohol based-drug delivery systems for cancer treatment
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T16:55:41Z
dc.journal.volume
600
dc.journal.pagination
1-11
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Rivera Hernández, Gabriela. Instituto Tecnológico de Monterrey; México. Universidad Nacional de Quilmes; Argentina
dc.description.fil
Fil: Antunes Ricardo, Marilena. Instituto Tecnológico de Monterrey; México
dc.description.fil
Fil: Martínez Morales, Patricia. Consejo Nacional de Ciencia y Tecnología; México. Centro de Investigación Biomédica de Oriente; México
dc.description.fil
Fil: Sanchez, Mirna Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB | Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular. Grupo Vinculado al IMBICE - Grupo de Biología Estructural y Biotecnología - Universidad Nacional de Quilmes - GBEyB; Argentina
dc.journal.title
International Journal Of Pharmaceutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0378517321002830
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.ijpharm.2021.120478
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