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dc.contributor.author
Konrath, Eduardo Luis
dc.contributor.author
Ortega, María Gabriela
dc.contributor.author
Bordignon, Sergio de Loreto
dc.contributor.author
Apel, Miriam Anders
dc.contributor.author
Henriques, Amalia Teresinha
dc.contributor.author
Cabrera, Jose Luis
dc.date.available
2017-06-13T14:04:14Z
dc.date.issued
2011-10
dc.identifier.citation
Konrath, Eduardo Luis; Ortega, María Gabriela; Bordignon, Sergio de Loreto; Apel, Miriam Anders; Henriques, Amalia Teresinha; et al.; Alkaloid profiling and anticholinesterase activity of south american Lycopodiaceae species; Taylor & Francis Ltd; Journal Of Enzyme Inhibition And Medicinal Chemistry; 28; 1; 10-2011; 218-222
dc.identifier.issn
1475-6366
dc.identifier.uri
http://hdl.handle.net/11336/18079
dc.description.abstract
The alkaloid extracts of four Huperzia and one Lycopodiella species, from Brazilian habitats, were tested for their in vitro anticholinesterase activities. IC(50) values showed a potent acetylcholinesterase inhibition for H. reflexa (0.11 ± 0.05 μg/mL), followed by H. quadrifariata (2.0 ± 0.3 μg/mL), H. acerosa (5.5 ± 0.9 μg/mL), H. heterocarpon (25.6 ± 2.7 μg/mL) and L. cernua (42.6 ± 1.5 μg/mL). A lower inhibition of butyrylcholinesterase was observed for all species with the exception of H. heterocarpon (8.3 ± 0.9 μg/mL), whose alkaloid extract presented a selectivity for pseudocholinesterase. Moreover, the chemical study of the bioactive extracts performed by GC-MS, revealed the presence of a number of Lycopodium alkaloids belonging to the lycopodane, flabellidane and cernuane groups. Surprisingly, the potent acetylcholinesterase inhibitors huperzines A and B were not detected in the extracts, suggesting that other alkaloids may be responsible for such an effect.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis Ltd
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Huperzia Acerosa
dc.subject
Huperzia Heterocarpon
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Huperzia Quadrifariata
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Huperzia Reflexa
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Otras Ciencias Químicas
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Alkaloid profiling and anticholinesterase activity of south american Lycopodiaceae species
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-30T18:24:00Z
dc.identifier.eissn
1475-6374
dc.journal.volume
28
dc.journal.number
1
dc.journal.pagination
218-222
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Konrath, Eduardo Luis. Universidade Federal do
Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós Graduação em Ciências Farmacêuticas; Brasil
dc.description.fil
Fil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia. Catedra de Farmacognosia; Argentina
dc.description.fil
Fil: Bordignon, Sergio de Loreto. Centro Universitário La Salle; Brasil
dc.description.fil
Fil: Apel, Miriam Anders. Universidade Federal do
Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós Graduação em Ciências Farmacêuticas; Brasil
dc.description.fil
Fil: Henriques, Amalia Teresinha. Universidade Federal do
Rio Grande do Sul. Faculdade de Farmácia. Programa de Pós Graduação em Ciências Farmacêuticas; Brasil
dc.description.fil
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia. Catedra de Farmacognosia; Argentina
dc.journal.title
Journal Of Enzyme Inhibition And Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/full/10.3109/14756366.2011.633908
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.3109/14756366.2011.633908
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