Self-assembled nanostructures of L-ascorbic acid alkyl esters support monomeric amphotericin B

Amphotericin B (AmB) is a highly effective antimicrobial, with broad antimycotic and antiparasitic effect. However, AmB poor water-solubilisation and aggregation tendency limits its use for topical applications. We studied the capacity of nanostructures formed by alkyl esters of L-ascorbic acid (ASCn) to solubilise AmB and tested the relationship between the prevalence of the monomeric form of AmB and its effectiveness as antimicrobial agent.

Palabras clave: AMPHIPHILIC DRUGS , COAGELS , DRUG CARRIERS , LANGMUIR MONOLAYERS , POLYENE MACROLIDES

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

Identificadores

URI: http://hdl.handle.net/11336/180788

URL: https://linkinghub.elsevier.com/retrieve/pii/S2405844021001614

DOI: http://dx.doi.org/10.1016/j.heliyon.2021.e06056

Colecciones

Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)

Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA

Citación

Nocelli, Natalia Estefanía; Zulueta Díaz, Yenisleidy de Las Mercedes; Millot, Marine; Colazo, María Luz; Vico, Raquel Viviana; et al.; Self-assembled nanostructures of L-ascorbic acid alkyl esters support monomeric amphotericin B; Elsevier Ltd; Heliyon; 7; 1; 1-2021; 1-14

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