Artículo
Ocular biocompatibility of polyquaternium 10 gel: functional and morphological results
Alasino, Roxana Valeria
; Garcia, Luciana Guadalupe; Gramajo, Ana Laura
; Pusterla, Juan Pablo; Beltramo, Dante Miguel
; Luna, José Domingo
Fecha de publicación:
02/2015
Editorial:
Springer
Revista:
Journal of Materials Science: Materials In Medicine
ISSN:
0957-4530
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
This paper deals with the characterization study of topical and intraocular biocompatibility and toxicity of cationic hydroxyethylcellulose Polyquaternium 10 (PQ10). It also evaluates the rheological properties of gels. The cytotoxicity assays were done in two cell lines: HEp-2 and VERO (human larynx epidermoid carcinoma cell and African green monkey kidney cells respectively). For the in vivo study, New Zealand albino rabbits were used. The in vitro cytotoxic activity of PQ10 shows no statistically significant differences in relation to the control of hydroxypropylmethylcellulose (HPMC) in any of the cell lines used in this study. Similarly, the signs of inflammation observed after treatment showed no significant difference between the groups of animals treated with the polymer compared to the control group. Normal histological characteristics were seen in both groups with no histological inflammatory reaction. After 1 month of the intracameral application of 2 % PQ10 (treatment group) or 0.3 % HPMC (control group), electroretinograms showed similar levels of a- and b-waves latencies and amplitude. In summary, PQ10 gel was well tolerated in these experiments, with proper monitoring, it could stand as a new alternative in the development of ophthalmic viscosurgical devices.
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Articulos(CCT - CORDOBA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - CORDOBA
Citación
Alasino, Roxana Valeria; Garcia, Luciana Guadalupe; Gramajo, Ana Laura; Pusterla, Juan Pablo; Beltramo, Dante Miguel; et al.; Ocular biocompatibility of polyquaternium 10 gel: functional and morphological results; Springer; Journal of Materials Science: Materials In Medicine; 26; 2; 2-2015; 1-10
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