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dc.contributor.author
Pereira Ramos, Pablo Ivan
dc.contributor.author
Flores Custodio, Gregori Marlon
dc.contributor.author
Quispe Saji, Guadalupe del Rosario
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dc.contributor.author
Cardoso, Thiago
dc.contributor.author
Luchetti da Silva, Gisele
dc.contributor.author
Braun, Graziela
dc.contributor.author
Martins, Williams
dc.contributor.author
Girardello, Raquel
dc.contributor.author
Ribeiro de Vasconcellos, Ana Teresa
dc.contributor.author
Fernandez, Elmer Andres
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dc.contributor.author
Gales, Cristina
dc.contributor.author
Nicolas, Marisa
dc.date.available
2022-12-02T13:31:17Z
dc.date.issued
2016-10
dc.identifier.citation
Pereira Ramos, Pablo Ivan; Flores Custodio, Gregori Marlon; Quispe Saji, Guadalupe del Rosario; Cardoso, Thiago; Luchetti da Silva, Gisele; et al.; The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets; BioMed Central; BMC Genomics; 17; 10-2016; 1-16
dc.identifier.issn
1471-2164
dc.identifier.uri
http://hdl.handle.net/11336/179977
dc.description.abstract
Background: The emergence of multidrug-resistant Klebsiella pneumoniae is a major public health concern. Many K. pneumoniae infections can only be treated when resorting to last-line drugs such as polymyxin B (PB). However, resistance to this antibiotic is also observed, although insufficient information is described on its mode of action as well as the mechanisms used by resistant bacteria to evade its effects. We aimed to study PB resistance and the influence of abiotic stresses in a clinical K. pneumoniae strain using whole transcriptome profiling. Results: We sequenced 12 cDNA libraries of K. pneumoniae Kp13 bacteria, from two biological replicates of the original strain Kp13 (Kp13) and five derivative strains: induced high-level PB resistance in acidic pH (Kp13pH), magnesium deprivation (Kp13Mg), high concentrations of calcium (Kp13Ca) and iron (Kp13Fe), and a control condition with PB (Kp13PolB). Our results show the involvement of multiple regulatory loci that differentially respond to each condition as well as a shared gene expression response elicited by PB treatment, and indicate the participation of two-regulatory components such as ArcA-ArcB, which could be involved in re-routing the K. pneumoniae metabolism following PB treatment. Modules of co-expressed genes could be determined, which correlated to growth in acid stress and PB exposure. We hypothesize that polymyxin B induces metabolic shifts in K. pneumoniae that could relate to surviving against the action of this antibiotic. Conclusions: We obtained whole transcriptome data for K. pneumoniae under different environmental conditions and PB treatment. Our results supports the notion that the K. pneumoniae response to PB exposure goes beyond damaged membrane reconstruction and involves recruitment of multiple gene modules and intracellular targets.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANTIBIOTIC RESISTANCE
dc.subject
KLEBSIELLA PNEUMONIAE
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PATHOGEN
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POLYMYXIN B
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RNA-SEQ
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TRANSCRIPTOMICS
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The polymyxin B-induced transcriptomic response of a clinical, multidrug-resistant Klebsiella pneumoniae involves multiple regulatory elements and intracellular targets
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-12-01T14:21:27Z
dc.journal.volume
17
dc.journal.pagination
1-16
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Pereira Ramos, Pablo Ivan. Fundación Oswaldo Cruz; Brasil
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Fil: Flores Custodio, Gregori Marlon. No especifíca;
dc.description.fil
Fil: Quispe Saji, Guadalupe del Rosario. No especifíca;
dc.description.fil
Fil: Cardoso, Thiago. No especifíca;
dc.description.fil
Fil: Luchetti da Silva, Gisele. No especifíca;
dc.description.fil
Fil: Braun, Graziela. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Martins, Williams. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Girardello, Raquel. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Ribeiro de Vasconcellos, Ana Teresa. No especifíca;
dc.description.fil
Fil: Fernandez, Elmer Andres. Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
dc.description.fil
Fil: Gales, Cristina. Universidade Federal de Sao Paulo; Brasil
dc.description.fil
Fil: Nicolas, Marisa. No especifíca;
dc.journal.title
BMC Genomics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12864-016-3070-y
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