Artículo
Epistructural tension promotes protein associations
Fecha de publicación:
05/2012
Editorial:
American Physical Society
Revista:
Physical Review Letters
ISSN:
0031-9007
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Epistructural tension is the reversible work per unit area required to span the aqueous interface of a soluble protein structure. The parameter accounts for the free-energy cost of imperfect hydration, involving water molecules with a shortage of hydrogen bonding partnerships relative to bulk levels. The binding hot spots along protein-protein interfaces are identified with residues that contribute significantly to the epistructural tension in the free subunits. Upon association, such residues either displace or become deprived of low-coordination vicinal water molecules.
Palabras clave:
Biophysics
,
Biological Interface
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Identificadores
Colecciones
Articulos(IAM)
Articulos de INST.ARG.DE MATEMATICAS "ALBERTO CALDERON"
Articulos de INST.ARG.DE MATEMATICAS "ALBERTO CALDERON"
Citación
Fernandez, Ariel; Epistructural tension promotes protein associations; American Physical Society; Physical Review Letters; 108; 5-2012; 188102-188102
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