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dc.contributor.author
Lelic, D.
dc.contributor.author
Fischer, I. W. D.
dc.contributor.author
Olesen, A. E.
dc.contributor.author
Mørch, C. D.
dc.contributor.author
Arguissain, F. G.
dc.contributor.author
Biurrun Manresa, José Alberto
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dc.contributor.author
Dahan, A.
dc.contributor.author
Drewes, A. M.
dc.date.available
2022-11-28T10:54:01Z
dc.date.issued
2016-11
dc.identifier.citation
Lelic, D.; Fischer, I. W. D.; Olesen, A. E.; Mørch, C. D.; Arguissain, F. G.; et al.; Venlafaxine and Oxycodone Effects on Human Spinal and Supraspinal Pain Processing: a Randomized Cross-Over Trial; Wiley Blackwell Publishing, Inc; European Journal of Neuroscience; 44; 11; 11-2016; 2966-2974
dc.identifier.issn
1460-9568
dc.identifier.uri
http://hdl.handle.net/11336/179114
dc.description.abstract
Severe pain is often treated with opioids. Antidepressants that inhibit serotonin and norepinephrine reuptake (SNRI) have also shown a pain relieving effect, but for both SNRI and opioids, the specific mode of action in humans remains vague. This study investigated how oxycodone and venlafaxine affect spinal and supraspinal pain processing. Twenty volunteers were included in this randomized cross-over study comparing 5-day treatment with venlafaxine, oxycodone and placebo. As a proxy of the spinal pain transmission, the nociceptive withdrawal reflex (NWR) to electrical stimulation on the sole of the foot was recorded at the tibialis anterior muscle before and after 5 days of treatment. For the supraspinal activity, 61-channel electroencephalogram evoked potentials (EPs) to the electrical stimulations were simultaneously recorded. Areas under curve (AUCs) of the EMG signals were analyzed. Latencies and AUCs were computed for the major EP peaks and brain source analysis was done. The NWR was decreased in venlafaxine arm (P = 0.02), but the EP parameters did not change. Oxycodone increased the AUC of the EP response (P = 0.04). Oxycodone also shifted the cingulate activity anteriorly in the mid-cingulate-operculum network (P < 0.01), and the cingulate activity was increased while the operculum activity was decreased (P = 0.02). Venlafaxine exerts its effects on the modulation of spinal nociceptive transmission, which may reflect changes in balance between descending inhibition and descending facilitation. Oxycodone, on the other hand, exerts its effects at the cortical level. This study sheds light on how opioids and SNRI drugs modify the human central nervous system and where their effects dominate.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BRAIN SOURCE LOCALIZATION
dc.subject
EEG
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EVOKED POTENTIALS
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NOCICEPTIVE WITHDRAWAL REFLEXES
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OPIOID
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SEROTONIN AND NOREPINEPHRINE REUPTAKE
dc.subject.classification
Ingeniería Médica
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dc.subject.classification
Ingeniería Médica
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Venlafaxine and Oxycodone Effects on Human Spinal and Supraspinal Pain Processing: a Randomized Cross-Over Trial
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-11-24T13:48:43Z
dc.identifier.eissn
0953-816X
dc.journal.volume
44
dc.journal.number
11
dc.journal.pagination
2966-2974
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Lelic, D.. Aalborg University Hospital; Alemania
dc.description.fil
Fil: Fischer, I. W. D.. Aalborg University Hospital; Alemania
dc.description.fil
Fil: Olesen, A. E.. Aalborg University Hospital; Alemania
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Fil: Mørch, C. D.. Aalborg University; Dinamarca
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Fil: Arguissain, F. G.. Aalborg University; Dinamarca
dc.description.fil
Fil: Biurrun Manresa, José Alberto. Aalborg University; Dinamarca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Dahan, A.. Leiden University. Leiden University Medical Center; Países Bajos
dc.description.fil
Fil: Drewes, A. M.. Aalborg University Hospital; Alemania
dc.journal.title
European Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ejn.13443
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